Lindenschmidt E G, Becker H D
Z Gastroenterol. 1979 Dec;17(12):820-6.
The basic and with pentagastrin stimulated (dose response) secretion of acid and proteolytic activity of the stomach were estimated at five healthy volunteers before and after a six-week-antacid-therapy as well as at ten patients with duodenal ulcer disease. After a six-week-antacid-therapy the BAO and the basic proteolytic activity were reduced for 50% as compared to the healthy volunteers without it while the maximal stimulated secretion of acid and proteolytic enzymes was not altered. After a three-day-antacid-therapy these changes did not occur. The basic acid output (BAO) was increased for 60% and the basic secretion of proteolytic enzymes was increased for 50% at duodenal ulcer patients. The changes of the gastric juice volumes at the different steps of stimulation and within the three groups of patients do not seem to be correlated constantly to the changes of secretion of acid and proteolytic activity. After a three-day-antacid-therapy, however, the volume of the basic and stimulated gastric juice turned out to be identically reduced as after a longtime antacid therapy. These results suggest that the secretion of acid, proteolytic activity and gastric juice occur independently.
在六名健康志愿者接受为期六周的抗酸治疗前后，以及在十名十二指肠溃疡患者中，评估了基础胃酸分泌以及五肽胃泌素刺激下（剂量反应）的胃酸分泌和胃蛋白酶活性。与未接受抗酸治疗的健康志愿者相比，经过六周抗酸治疗后，基础胃酸分泌量（BAO）和基础胃蛋白酶活性降低了50%，而最大刺激胃酸分泌和胃蛋白酶的分泌未发生改变。经过三天抗酸治疗后，未出现这些变化。十二指肠溃疡患者的基础胃酸分泌量（BAO）增加了60%，基础胃蛋白酶分泌增加了50%。在不同刺激阶段以及三组患者中，胃液量的变化似乎与胃酸分泌和胃蛋白酶活性的变化并无恒定关联。然而，经过三天抗酸治疗后，基础胃液量和刺激后胃液量的减少情况与长期抗酸治疗后相同。这些结果表明，胃酸分泌、胃蛋白酶活性和胃液分泌是独立发生的。
