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动脉发自肺动脉异常左冠状动脉的外科治疗进展。

Progress of surgical treatment of anomalous left coronary artery from the pulmonary artery.

机构信息

Department of Cardiovascular Surgery, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital, Beijing, China.

出版信息

Cardiol Young. 2024 Jul;34(7):1411-1423. doi: 10.1017/S1047951124025381. Epub 2024 Oct 25.

Abstract

Anomalous left coronary artery from the pulmonary artery is a rare CHD. It is the most common type of anomalous coronary origin. It may cause myocardial ischaemia or infarction, mitral regurgitation, congestive heart failure, and early death in infancy if left untreated. Surgery is the only treatment for anomalous left coronary artery from the pulmonary artery. In recent years, with advancements in surgical techniques and the widespread utilisation of extracorporeal cardiac assist devices such as extracorporeal membrane oxygenation, the treatment outcomes for anomalous left coronary artery from the pulmonary artery have demonstrated significant improvements. However, the surgical indications and methods of anomalous left coronary artery from the pulmonary artery, especially the surgical methods of anomalous left coronary artery from the pulmonary artery with intramural coronary artery, and whether to treat mitral regurgitation at the same time are still controversial. The long-term complications and prognosis remain discouraging simultaneously, with significant variations in outcomes across different centres. The present review specifically addresses these aforementioned concerns. Based on the literature published at home and abroad, we found that no matter what type of anomalous left coronary artery from the pulmonary artery patients, even asymptomatic patients, regardless of the collateral circulation between the left and right coronary arteries, should immediately undergo surgical treatment to promote the recovery of left ventricular function. Based on different coronary artery anatomical morphology and preoperative cardiac function, the long-term follow-up results of individualised surgical treatment of anomalous left coronary artery from the pulmonary artery children show good prognosis, and most children have significant improvement in cardiac function. Patients with moderate to severe mitral regurgitation should undergo mitral valve operation at the same time as anomalous left coronary artery from the pulmonary artery repair. Mitral valvuloplasty can quickly improve mitral regurgitation and promote the early recovery of cardiac function after operation, and does not increase the risk of operation. Mechanical circulatory support is a safe and effective means of early postoperative transition for children with severe anomalous left coronary artery from the pulmonary artery. Anomalous left coronary artery from the pulmonary artery with intramural coronary artery is a rare anomaly. According to different anatomical types, different surgical methods can be used for anatomical correction, and satisfactory early and mid-term results can be obtained.

摘要

法洛四联症是一种罕见的 CHD。它是最常见的异常冠状动脉起源类型。如果不治疗,可能导致心肌缺血或梗死、二尖瓣反流、充血性心力衰竭和婴儿期早期死亡。手术是治疗法洛四联症的唯一方法。近年来,随着手术技术的进步和体外心脏辅助设备(如体外膜肺氧合)的广泛应用,法洛四联症的治疗效果有了显著改善。然而,法洛四联症的手术指征和方法,特别是法洛四联症伴冠状动脉壁内冠状动脉的手术方法,以及是否同时治疗二尖瓣反流,仍存在争议。长期并发症和预后仍然令人沮丧,不同中心的结果差异很大。本综述专门针对上述问题。根据国内外文献报道,我们发现,无论何种类型的法洛四联症患者,即使是无症状患者,无论左右冠状动脉之间的侧支循环如何,都应立即进行手术治疗,以促进左心室功能的恢复。根据不同的冠状动脉解剖形态和术前心功能,对法洛四联症患儿进行个体化手术治疗的长期随访结果显示预后良好,大多数患儿心功能有显著改善。中重度二尖瓣反流患者应在法洛四联症修复的同时行二尖瓣手术。二尖瓣成形术可迅速改善二尖瓣反流,促进术后心功能早期恢复,且不会增加手术风险。机械循环支持是严重法洛四联症患儿术后早期过渡的一种安全有效的手段。法洛四联症伴冠状动脉壁内冠状动脉是一种罕见的异常。根据不同的解剖类型,可以采用不同的手术方法进行解剖矫正,获得满意的早期和中期结果。

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