Department of Paediatric Surgery, Tianjin Medical University General Hospital, Tianjin, China.
Department of Respiratory and Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin, China.
Front Endocrinol (Lausanne). 2024 Oct 10;15:1418657. doi: 10.3389/fendo.2024.1418657. eCollection 2024.
Carcinoembryonic antigen (CEA) and calcitonin (Ctn) are pivotal biomarkers in the diagnosis and management of medullary thyroid carcinoma (MTC). However, their diagnostic reliability in perioperative period remains a topic of ongoing debate. This review synthesizes researches on perioperative fluctuations in CEA and Ctn levels, and evaluates the impact of their different combinations on MTC diagnosis, treatment decisions, and prognosis. Our findings highlight it is crucial to understand and interpret the various combinations of CEA and Ctn fluctuations within a clinical context. Furthermore, to reduce diagnostic errors and improve patient outcomes, we recommend follow-up diagnostic and treatment protocols designed to address the potential pitfalls associated with the use of these biomarkers.
癌胚抗原（CEA）和降钙素（Ctn）是诊断和治疗甲状腺髓样癌（MTC）的关键生物标志物。然而，它们在围手术期的诊断可靠性仍然是一个持续争论的话题。本综述综合了关于 CEA 和 Ctn 水平在围手术期波动的研究，并评估了它们不同组合对 MTC 诊断、治疗决策和预后的影响。我们的研究结果强调，在临床背景下理解和解释 CEA 和 Ctn 波动的各种组合至关重要。此外，为了减少诊断错误和改善患者预后，我们建议制定后续诊断和治疗方案，以解决使用这些生物标志物相关的潜在问题。
