Durtschi Maxwell S, Pham Nicole S, Hwang Calvin E
Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, USA.
Cureus. 2024 Sep 23;16(9):e70041. doi: 10.7759/cureus.70041. eCollection 2024 Sep.
We aimed to evaluate the efficacy of measuring transaminase levels to determine the resolution of splenomegaly in athletes diagnosed with infectious mononucleosis (IM).
We collected serial aspartate aminotransferase (AST) and alanine transaminase (ALT) levels and ultrasound-measured spleen sizes in university athletes who had been diagnosed with IM. Our study included seven university-aged athletes from a single institution. Patients received serial liver function tests (LFT) and splenic ultrasound testing until resolution of symptoms and full return to sport. The effects of AST, ALT, and days from symptom onset were analyzed using multivariable mixed-effects linear regression models.
Levels of AST and ALT were significantly correlated with spleen size. For each 10-unit increase in AST and ALT values, spleen size increased by 0.1 cm (p = 0.007) and 0.09 cm (p = 0.008), respectively. Decreasing levels of ALT and AST correlated with a decrease in spleen size. Normalization of AST/ALT values correlated with return of spleen size to baseline.
Liver function testing may be useful in the return-to-play decision-making process for athletes with IM.
我们旨在评估检测转氨酶水平对诊断为传染性单核细胞增多症（IM）的运动员脾肿大消退情况的判定效果。
我们收集了被诊断为IM的大学运动员的系列天门冬氨酸氨基转移酶（AST）和丙氨酸氨基转移酶（ALT）水平，以及通过超声测量的脾脏大小。我们的研究纳入了来自单一机构的7名大学年龄段运动员。患者接受系列肝功能检查（LFT）和脾脏超声检查，直至症状消退且完全恢复运动。使用多变量混合效应线性回归模型分析AST、ALT及症状出现天数的影响。
AST和ALT水平与脾脏大小显著相关。AST和ALT值每增加10个单位，脾脏大小分别增加0.1厘米（p = 0.007）和0.09厘米（p = 0.008）。ALT和AST水平降低与脾脏大小减小相关。AST/ALT值恢复正常与脾脏大小恢复至基线相关。
肝功能检查可能有助于IM运动员重返比赛的决策过程。
