Rausch Manuel K
Departments of Aerospace Engineering & Engineering Mechanics, Biomedical Engineering, Oden Institute for Computational Engineering and Sciences, University of Texas at Austin, Austin, TX, USA.
Curr Opin Biomed Eng. 2020 Sep;15:10-15. doi: 10.1016/j.cobme.2019.12.008. Epub 2019 Dec 28.
The atrioventricular heart valves, i.e., the mitral valve and the tricuspid valve, play vital roles in our cardiovascular system. Disease of these valves is therefore a significant source of morbidity and mortality. Unfortunately, current treatment options are suboptimal with significant rates of failure. It was only recently that we have begun to appreciate that the atrioventricular heart valve leaflets are not just passive flaps, but actively (mal-)adapting tissues. This discovery sheds new light on disease mechanisms and provides, thus, possible pathways to new treatments. In this current opinion piece, we examine the state of our knowledge about the (mal-)adaptive mechanisms (physiological and pathological growth and remodeling) of the atrioventricular heart valves. Furthermore, we review the evidence that suggests that valve maladaptation may be a target for pharmacological treatment of diseased valves which, in the future, could transform clinical practice.
房室心脏瓣膜，即二尖瓣和三尖瓣，在我们的心血管系统中发挥着至关重要的作用。因此，这些瓣膜的疾病是发病和死亡的重要原因。不幸的是，目前的治疗选择并不理想，失败率很高。直到最近，我们才开始认识到房室心脏瓣膜小叶不仅仅是被动的瓣叶，而是积极（异常）适应的组织。这一发现为疾病机制提供了新的线索，从而为新的治疗方法提供了可能的途径。在这篇当前的观点文章中，我们研究了我们对房室心脏瓣膜（异常）适应机制（生理和病理生长及重塑）的了解情况。此外，我们回顾了证据，表明瓣膜适应不良可能是患病瓣膜药物治疗的一个靶点，未来可能会改变临床实践。
