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RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer.RARRES2 调节脂质代谢重编程以介导三阴性乳腺癌脑转移的发展。
Mil Med Res. 2023 Jul 25;10(1):34. doi: 10.1186/s40779-023-00470-y.
2
Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases.通过靶向 DRP1 限制线粒体可塑性可诱导代谢重编程并减少乳腺癌脑转移。
Nat Cancer. 2023 Jun;4(6):893-907. doi: 10.1038/s43018-023-00563-6. Epub 2023 May 29.
3
FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS.乳腺癌脑转移需要脂肪酸合成。
Nat Cancer. 2021 Apr;2(4):414-428. doi: 10.1038/s43018-021-00183-y. Epub 2021 Apr 1.
4
Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment is dependent on Stearoyl CoA desaturase.急性淋巴细胞白血病对中枢神经系统微环境的代谢适应依赖于硬脂酰辅酶 A 去饱和酶。
Nat Cancer. 2020 Oct;1(10):998-1009. doi: 10.1038/s43018-020-00115-2. Epub 2020 Sep 28.
5
A metastasis map of human cancer cell lines.人类癌细胞系的转移图谱。
Nature. 2020 Dec;588(7837):331-336. doi: 10.1038/s41586-020-2969-2. Epub 2020 Dec 9.
6
Polyunsaturated Fatty Acids from Astrocytes Activate PPARγ Signaling in Cancer Cells to Promote Brain Metastasis.星形胶质细胞来源的多不饱和脂肪酸激活癌细胞中的 PPARγ 信号通路促进脑转移。
Cancer Discov. 2019 Dec;9(12):1720-1735. doi: 10.1158/2159-8290.CD-19-0270. Epub 2019 Oct 2.
7
The biology of brain metastases-translation to new therapies.脑转移瘤的生物学——向新疗法的转化。
Nat Rev Clin Oncol. 2011 Jun;8(6):344-56. doi: 10.1038/nrclinonc.2011.58. Epub 2011 Apr 12.

维甲酸受体反应蛋白2与脂质代谢重编程：对脑转移的新见解

Retinoic acid receptor responder 2 and lipid metabolic reprogramming: A new insight into brain metastasis.

作者信息

Wang Lulu, Gao Yan

机构信息

Department of Human Anatomy, School of Basic Medical Sciences Capital Medical University Beijing China.

Beijing Key Laboratory of Cancer Invasion and Metastasis Research Beijing China.

出版信息

Cancer Innov. 2024 Oct 24;3(6):e148. doi: 10.1002/cai2.148. eCollection 2024 Dec.

DOI:10.1002/cai2.148
PMID:39450411
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11499704/
Abstract

The brain is a common metastatic site for carcinoma, and metabolic reprogramming is crucial for organ-tropic metastatic formation. Li et al. found RARRES2 deficiency affected lipid metabolic reprogramming through PTEN-mTOR-SREBP1 pathway and promoted BCBrM. Other studies revealed that lipid metabolic reprogramming is part of metabolic adaptation to central nervous system. Overall, there is an intricate connection between lipid metabolism and brain metastases, and disrupting this connection may be a potential therapeutic target for BCBrM treatment.

摘要

脑是癌常见的转移部位，代谢重编程对于器官特异性转移灶的形成至关重要。李等人发现视黄醇脱氢酶12（RARRES2）缺陷通过磷酸酶和张力蛋白同源物（PTEN）-雷帕霉素靶蛋白（mTOR）-固醇调节元件结合蛋白1（SREBP1）途径影响脂质代谢重编程，并促进乳腺癌脑转移（BCBrM）。其他研究表明，脂质代谢重编程是对中枢神经系统代谢适应的一部分。总体而言，脂质代谢与脑转移之间存在复杂的联系，破坏这种联系可能是BCBrM治疗的一个潜在治疗靶点。