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更大的图景:通过联合“组学”分析洞察环境化学物质与血脂异常。

A Bigger Big Picture: Insights on Environmental Chemicals and Dyslipidemia through Combined "Omic" Analyses.

出版信息

Environ Health Perspect. 2024 Oct;132(10):104002. doi: 10.1289/EHP15932. Epub 2024 Oct 25.

DOI:10.1289/EHP15932
PMID:39450969
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11504649/
Abstract

Exposures to chemicals, including phthalates, triphenyl phosphate, and dibutyl phosphate, have been associated with increased levels of lipid markers, such as elevated low-density lipoprotein.

摘要

接触化学物质,包括邻苯二甲酸酯、磷酸三苯酯和磷酸二丁酯,与脂质标志物水平升高有关,如升高的低密度脂蛋白。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d2a/11504649/3bb33bdf2eac/ehp15932_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d2a/11504649/387a1f62353b/ehp15932_abstract.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d2a/11504649/3bb33bdf2eac/ehp15932_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d2a/11504649/387a1f62353b/ehp15932_abstract.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d2a/11504649/3bb33bdf2eac/ehp15932_f1.jpg

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本文引用的文献

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Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study.暴露组学全基因组关联分析揭示与血脂异常相关的环境化学物质:来自 BAPE 研究的中国健康老年人的面板研究。
Environ Health Perspect. 2024 Sep;132(9):97005. doi: 10.1289/EHP13864. Epub 2024 Sep 6.
2
The Heart of the World.世界的中心。
Glob Heart. 2024 Jan 25;19(1):11. doi: 10.5334/gh.1288. eCollection 2024.
3
Degradation and phosphorus immobilization treatment of organophosphate esters hazardous waste by Fe-Mn bimetallic oxide.
Fe-Mn 双金属氧化物对有机磷酸酯危险废物的降解和磷固定处理。
J Hazard Mater. 2023 May 5;449:131049. doi: 10.1016/j.jhazmat.2023.131049. Epub 2023 Feb 20.
4
The exposome in practice: an exploratory panel study of biomarkers of air pollutant exposure in Chinese people aged 60-69 years (China BAPE Study).实践中的暴露组:一项针对60-69岁中国人空气污染暴露生物标志物的探索性小组研究(中国BAPE研究)
Environ Int. 2021 Dec;157:106866. doi: 10.1016/j.envint.2021.106866. Epub 2021 Sep 12.
5
Mechanisms and regulation of cholesterol homeostasis.胆固醇稳态的机制和调节。
Nat Rev Mol Cell Biol. 2020 Apr;21(4):225-245. doi: 10.1038/s41580-019-0190-7. Epub 2019 Dec 17.
6
Diverse Biological Functions of Sphingolipids in the CNS: Ceramide and Sphingosine Regulate Myelination in Developing Brain but Stimulate Demyelination during Pathogenesis of Multiple Sclerosis.鞘脂类在中枢神经系统中的多种生物学功能:神经酰胺和鞘氨醇在发育中的大脑中调节髓鞘形成,但在多发性硬化症发病过程中刺激脱髓鞘。
J Neurol Psychol. 2017 Dec;5(1). doi: 10.13188/2332-3469.1000035. Epub 2017 Dec 23.
7
Differences in Cardiovascular Aging in Men and Women.男女心血管衰老的差异。
Adv Exp Med Biol. 2018;1065:389-411. doi: 10.1007/978-3-319-77932-4_25.
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Ann Intern Med. 2017 Dec 5;167(11):ITC81-ITC96. doi: 10.7326/AITC201712050.
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Sphingolipids and their metabolism in physiology and disease.鞘脂及其代谢在生理和疾病中的作用。
Nat Rev Mol Cell Biol. 2018 Mar;19(3):175-191. doi: 10.1038/nrm.2017.107. Epub 2017 Nov 22.
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The Lancet Commission on pollution and health.柳叶刀污染与健康委员会
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