Silva-Lalucci Marielle Priscila de Paula, Marques Déborah Cristina de Souza, Ryal Joed Jacinto, Marques Marilene Ghiraldi de Souza, Perli Victor Augusto Santos, Sordi Ana Flávia, de Moraes Solange Marta Franzoi, Valdés-Badilla Pablo, Andreato Leonardo Vidal, Branco Braulio Henrique Magnani
Interdisciplinary Laboratory of Intervention in Health Promotion, Cesumar Institute of Science, Maringá 87050-390, Brazil.
Graduate Program in Health Promotion, Cesumar University, Maringá 87050-390, Brazil.
Healthcare (Basel). 2024 Oct 14;12(20):2034. doi: 10.3390/healthcare12202034.
BACKGROUND/OBJECTIVES: Considering the diverse symptomatology of COVID-19-ranging from mild to severe cases-multi-professional interventions are crucial for enhancing physical recovery, nutritional status, and mental health outcomes in affected patients. Thus, this study aimed to investigate the effects of such an intervention on health-related physical fitness and biomarkers in overweight COVID-19 survivors with varying degrees of symptom severity after 8 weeks and 16 weeks.
This non-randomized clinical trial included 59 overweight COVID-19 survivors (32 males and 27 females) divided into three groups: mild ( 31), moderate ( 13), and severe/critical ( 15). The participants underwent a multi-professional program and were assessed for anthropometric and body composition (primary outcome), as well as physical fitness and biochemical markers (secondary outcome) 8 and 16 weeks before the intervention.
After 8 weeks, time effects were observed for the maximum isometric handgrip strength ( < 0.001), maximum isometric lumbar-traction strength ( = 0.01), flexibility ( < 0.001), abdominal strength-endurance ( < 0.001), the sit-and-stand test ( < 0.001), maximum oxygen consumption ( < 0.001), and distance covered in the 6 min walk test ( < 0.001). Additionally, time effects were also observed for fat mass ( = 0.03), body fat percentage ( = 0.02), abdominal circumference ( = 0.01), total cholesterol ( < 0.001), low-density lipoproteins ( < 0.001), and glycated hemoglobin ( < 0.001), with lower values after multi-professional interventions. After 16 weeks, the systolic and diastolic blood pressure showed significant reductions independently of the intervention group ( < 0.001).
These findings suggest that multi-professional interventions can provide substantial benefits for post-COVID-19 patients, regardless of the severity of their initial symptoms.
背景/目的：考虑到新冠病毒疾病（COVID-19）症状多样，从轻症到重症不等，多专业干预对于促进受影响患者的身体恢复、营养状况和心理健康结果至关重要。因此，本研究旨在调查这种干预对8周和16周后不同症状严重程度的超重COVID-19康复者与健康相关的身体素质和生物标志物的影响。
这项非随机临床试验纳入了59名超重的COVID-19康复者（32名男性和27名女性），分为三组：轻症（31人）、中症（13人）和重症/危重症（15人）。参与者接受了多专业项目，并在干预前8周和16周对其进行人体测量和身体成分评估（主要结果），以及身体素质和生化指标评估（次要结果）。
8周后，观察到最大等长握力（P<0.001）、最大等长腰椎牵引力量（P = 0.01）、柔韧性（P<0.001）、腹部力量耐力（P<0.001）、坐立试验（P<0.001）、最大耗氧量（P<0.001）和6分钟步行试验中的行走距离（P<0.001）有时间效应。此外，还观察到脂肪量（P = 0.03）、体脂百分比（P = 0.02）、腹围（P = 0.01）、总胆固醇（P<0.001）、低密度脂蛋白（P<0.001）和糖化血红蛋白（P<0.001）有时间效应，多专业干预后这些指标值较低。16周后，收缩压和舒张压均显著降低，且与干预组无关（P<0.001）。
这些发现表明，无论初始症状的严重程度如何，多专业干预都可以为COVID-19康复患者带来实质性益处。
