Hosoi Hiroki, Tane Misato, Sogabe Makiko, Iwamoto Ryuta, Minoura Naoto, Murata Shogo, Mushino Toshiki, Nishikawa Akinori, Murata Shin-Ichi, Sonoki Takashi
Department of Hematology/Oncology, Wakayama Medical University, Wakayama 641-8509, Japan.
Department of Transfusion Medicine, Wakayama Medical University Hospital, Wakayama 641-8510, Japan.
Diagnostics (Basel). 2024 Oct 14;14(20):2285. doi: 10.3390/diagnostics14202285.
Flower-shaped nuclei in plasma cells are rare in multiple myeloma.
We report on an 88-year-old male who presented with a mass lesion in the clavicular region. A biopsy of the mass revealed an increase in mature plasma cells with round nuclei. In contrast, a bone marrow examination showed increased plasma cells with flower-shaped nuclei. The patient tested negative for human T-lymphotropic virus type-1 and was diagnosed with multiple myeloma.
While multiple myeloma is known for intra-tumor heterogeneity, reports of morphological heterogeneity based on the site of tumor sampling are limited. In this case, the presence of plasma cells with flower-shaped nuclei enabled the identification of site-dependent morphological tumor heterogeneity.
浆细胞中的花形核在多发性骨髓瘤中较为罕见。
我们报告一名88岁男性，其锁骨区域出现肿块病变。肿块活检显示成熟浆细胞增多，细胞核呈圆形。相比之下，骨髓检查显示花形核浆细胞增多。该患者1型人类嗜T淋巴细胞病毒检测呈阴性，被诊断为多发性骨髓瘤。
虽然多发性骨髓瘤以肿瘤内异质性著称，但基于肿瘤取样部位的形态学异质性报告有限。在此病例中，花形核浆细胞的存在使得能够识别部位依赖性形态学肿瘤异质性。
