Patel Parth B, Latt Sun, Ravi Karan, Razavi Mehdi
University of Central Florida College of Medicine, Orlando, FL 32827, USA.
Biionix (Bionic Materials, Implants & Interfaces) Cluster, Department of Medicine, University of Central Florida College of Medicine, Orlando, FL 32827, USA.
Biomimetics (Basel). 2024 Oct 20;9(10):645. doi: 10.3390/biomimetics9100645.
Nanomedicine, leveraging the unique properties of nanoparticles, has revolutionized the diagnosis and treatment of neurological diseases. Among various nanotechnological advancements, ultrasound-mediated drug delivery using micro- and nanobubbles offers promising solutions to overcome the blood-brain barrier (BBB), enhancing the precision and efficacy of therapeutic interventions. This review explores the principles, current clinical applications, challenges, and future directions of ultrasound-mediated drug delivery systems in treating stroke, brain tumors, neurodegenerative diseases, and neuroinflammatory disorders. Additionally, ongoing clinical trials and potential advancements in this field are discussed, providing a comprehensive overview of the impact of nanomedicine on neurological diseases.
纳米医学利用纳米颗粒的独特性质，彻底改变了神经疾病的诊断和治疗方式。在各种纳米技术进步中，使用微泡和纳米泡的超声介导药物递送为克服血脑屏障提供了有前景的解决方案，提高了治疗干预的精准性和有效性。本综述探讨了超声介导药物递送系统在治疗中风、脑肿瘤、神经退行性疾病和神经炎症性疾病方面的原理、当前临床应用、挑战及未来方向。此外，还讨论了该领域正在进行的临床试验和潜在进展，全面概述了纳米医学对神经疾病的影响。
