Kancheva Mihaela, Aronson Lauren, Pattilachan Tara, Sautto Francesco, Daines Benjamin, Thommes Donald, Shar Angela, Razavi Mehdi
College of Medicine, University of Central Florida, Orlando, FL 32827, USA.
Biionix (Bionic Materials, Implants & Interfaces) Cluster, Department of Medicine, College of Medicine, University of Central Florida, Orlando, FL 32827, USA.
J Funct Biomater. 2023 Jul 17;14(7):373. doi: 10.3390/jfb14070373.
Current radiologic and medication administration is systematic and has widespread side effects; however, the administration of microbubbles and nanobubbles (MNBs) has the possibility to provide therapeutic and diagnostic information without the same ramifications. Microbubbles (MBs), for instance, have been used for ultrasound (US) imaging due to their ability to remain in vessels when exposed to ultrasonic waves. On the other hand, nanobubbles (NBs) can be used for further therapeutic benefits, including chronic treatments for osteoporosis and cancer, gene delivery, and treatment for acute conditions, such as brain infections and urinary tract infections (UTIs). Clinical trials are also being conducted for different administrations and utilizations of MNBs. Overall, there are large horizons for the benefits of MNBs in radiology, general medicine, surgery, and many more medical applications. As such, this review aims to evaluate the most recent publications from 2016 to 2022 to report the current uses and innovations for MNBs.
当前的放射学和药物管理是系统性的，但存在广泛的副作用；然而，微泡和纳米泡（MNBs）的应用有可能在不产生相同后果的情况下提供治疗和诊断信息。例如，微泡（MBs）因其在超声波作用下能够停留在血管中，已被用于超声（US）成像。另一方面，纳米泡（NBs）可用于进一步的治疗益处，包括骨质疏松症和癌症的长期治疗、基因递送以及脑感染和尿路感染（UTIs）等急性病症的治疗。针对MNBs的不同给药方式和用途的临床试验也正在进行。总体而言，MNBs在放射学、普通医学、外科手术以及更多医疗应用方面有着广阔的益处前景。因此，本综述旨在评估2016年至2022年的最新出版物，以报告MNBs的当前用途和创新。
