Stanko R T, Adibi S A
Metabolism. 1986 Feb;35(2):182-6. doi: 10.1016/0026-0495(86)90121-6.
To assess the effects of oral intake of pyruvate and dihydroxyacetone on body composition and metabolism, rats were divided into two groups and pair-fed one of the following isocaloric diets for 112 days. The control diet was a liquid diet with the following caloric composition: 14% protein, 28% fat, and 58% carbohydrate. The experimental diet was the same as the control diet except for the partial substitution of carbohydrate content with pyruvate and dihydroxyacetone. Rats receiving the experimental diet gained less weight than rats receiving the control diet. This reduction in body weight appeared to be largely the result of inhibition of lipid accumulation. The experimental diet reduced body fat content by 32% without any significant effect on either protein or water content. Rats receiving the experimental diet did not have increased loss of calories in the stool, but had greater rates of heat production and energy expenditure, which was accompanied by an elevated plasma level of thyroxine. Furthermore, rats receiving the experimental diet had a smaller rate of lipid synthesis in their adipose tissue, and a reduced plasma insulin level. The data suggest that inhibition of gain in weight with the addition of pyruvate and dihydroxyacetone to the diet is the result of an increased loss of calories as heat at the expense of storage as lipid.
为评估口服丙酮酸和二羟基丙酮对身体成分及代谢的影响，将大鼠分为两组，分别成对喂食以下等热量饮食112天。对照饮食为一种液体饮食，其热量组成为：14%蛋白质、28%脂肪和58%碳水化合物。实验饮食与对照饮食相同，只是碳水化合物含量部分被丙酮酸和二羟基丙酮替代。接受实验饮食的大鼠比接受对照饮食的大鼠体重增加更少。体重减轻似乎主要是脂质积累受到抑制的结果。实验饮食使体脂含量降低了32%，而对蛋白质或水分含量没有任何显著影响。接受实验饮食的大鼠粪便中的热量损失没有增加，但产热率和能量消耗更高，同时血浆甲状腺素水平升高。此外，接受实验饮食的大鼠脂肪组织中的脂质合成速率较低，血浆胰岛素水平也降低。数据表明，饮食中添加丙酮酸和二羟基丙酮导致体重增加受到抑制，是热量以脂质储存为代价增加损失的结果。
