Soria-Comes Teresa, Climent-Gregori María, Maestu-Maiques Inmaculada, Inchaurraga-Álvarez Ignacio, Cuenca-Martínez Ferrán, Cauli Omar, Martínez-Arnau Francisco M
Medical Oncology Department, Hospital Universitario Doctor Peset, 46017 Valencia, Spain.
Pneumology Department, Hospital Universitario Doctor Peset, 46017 Valencia, Spain.
Clin Pract. 2024 Oct 18;14(5):2202-2216. doi: 10.3390/clinpract14050173.
Lung cancer carries a high burden of systemic symptoms, including in survivors, leading to a reduced quality of life (QoL). We assessed whether a 12-week multicomponent supervised exercise programme, including muscular strength and aerobic training, was beneficial in patients who had undergone surgery for early non-small cell lung cancer (NSCLC) in terms of physical performance, QoL, and metabolic and nutritional analytical parameters. Physical performance was measured by gait speed, handgrip strength, 30 s sit-to-stand (30s-STS) test repetitions, distance covered in the 6 min walk test (6MWT), and the Short Physical Performance Battery (SPPB) score. QoL was assessed with the EORTC-QLQ-C30 questionnaire. Blood glucose, cholesterol, triglycerides, total proteins, albumin, pre-albumin, creatinine, c-reactive protein, insulin-growth factor 1 (IGF-1), and the haemoglobin and hematocrit percentages were measured before and after the intervention in order to observe any beneficial effects related to metabolic markers. After the intervention, the mean scores for the 6MWT ( < 0.001), STS ( < 0.001), 6MWT ( < 0.01), and SPPB ( < 0.01) had significantly improved. However, handgrip strength and nutritional analytical were unchanged. The EORTC-QLQ-C30 functions and symptoms significantly improved after the intervention ( < 0.05 and < 0.01, respectively). A significant decrease in cholesterol, triglycerides, and IGF-1 and a significant increase in pre-albumin in blood was also observed post-intervention ( < 0.05). This supervised, community-based 12-week multicomponent was feasible (adherence rate 70.35%) and provided benefits not only to physical performance but also to the quality of life of patients with NSCLC.
肺癌会带来严重的全身症状负担，包括幸存者也会出现此类情况，进而导致生活质量（QoL）下降。我们评估了一项为期12周的多组分监督运动计划，包括肌肉力量和有氧训练，对于早期非小细胞肺癌（NSCLC）手术患者在身体机能、生活质量以及代谢和营养分析参数方面是否有益。身体机能通过步速、握力、30秒坐立（30s - STS）测试重复次数、6分钟步行测试（6MWT）所覆盖的距离以及简短身体机能量表（SPPB）得分来衡量。生活质量使用欧洲癌症研究与治疗组织核心生活质量问卷（EORTC - QLQ - C30）进行评估。在干预前后测量血糖、胆固醇、甘油三酯、总蛋白、白蛋白、前白蛋白、肌酐、C反应蛋白、胰岛素样生长因子1（IGF - 1）以及血红蛋白和血细胞比容百分比，以观察与代谢指标相关的任何有益效果。干预后，6MWT（<0.001）、STS（<0.001）、6MWT（<0.01）和SPPB（<0.01）的平均得分显著提高。然而，握力和营养分析结果未发生变化。干预后，EORTC - QLQ - C30的功能和症状显著改善（分别为<0.05和<0.01）。干预后还观察到血液中胆固醇、甘油三酯和IGF - 1显著降低，前白蛋白显著升高（<0.05）。这项基于社区的12周多组分监督运动计划是可行的（依从率70.35%），不仅对身体机能有益，而且对NSCLC患者的生活质量也有好处。
