Abu-Zaid Ahmed, Saleh Saleh A K, Adly Heba M, Baradwan Saeed, Alharran Abdullah M, Alhatm Mshal, Alzayed Mooza M, Alotaibi Muteb N, Saad Abdulbadih Rabih, Alfayadh Hessa Mohammed, Abuzaid Mohammed, Alomar Osama
Department of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah 24382, Saudi Arabia.
Diseases. 2024 Sep 25;12(10):228. doi: 10.3390/diseases12100228.
Recent studies indicate that vitamin D impacts male reproductive function, with deficiency linked to infertility. This review evaluates the effect of vitamin D supplementation on male fertility, focusing on total testosterone, free testosterone, the free androgen index (FAI), follicle-stimulating hormone (FSH), luteinizing hormone (LH), sex-hormone-binding globulin (SHBG), and estradiol.
We systematically searched Medline, Web of Science, Cochrane Library, and Scopus from their inception until July 2024 for randomized controlled trials (RCTs) involving adult males. The primary focus of these studies was on reproductive hormone parameters, analyzed using a random-effects meta-analysis and weighted mean difference (WMD). Evidence quality was assessed using ROB2 and GRADE. Meta-regression and dose-response analyses were performed.
Seventeen studies met the criteria for quantitative analysis. Vitamin D supplementation significantly increased total testosterone levels (WMD 0.38, 95% CI 0.06-0.70, n = 15, I = 67.03). However, it had no significant effect on other hormone parameters: free testosterone (WMD 0.00, 95% CI -0.02-0.03, n = 9, I = 48.12), FSH (WMD -0.02, 95% CI -0.57-0.53, n = 7, I = 48.72), LH (WMD -0.09, 95% CI -0.30-0.12, n = 8, I = 0.00), SHBG (WMD 0.73, 95% CI -1.14-2.61, n = 10, I = 69.05), FAI (WMD -0.92, 95% CI -2.12-0.27, n = 6, I = 0.00), and estradiol (WMD -0.02, 95% CI -2.95-2.92, n = 5, I = 20.63).
This meta-analysis shows that vitamin D supplementation may increase total testosterone levels in men. However, further well-designed RCTs are needed to determine vitamin D's effects on other reproductive hormone parameters.
近期研究表明，维生素D会影响男性生殖功能，维生素D缺乏与不育症有关。本综述评估了补充维生素D对男性生育能力的影响，重点关注总睾酮、游离睾酮、游离雄激素指数（FAI）、促卵泡激素（FSH）、黄体生成素（LH）、性激素结合球蛋白（SHBG）和雌二醇。
我们系统检索了Medline、科学网、Cochrane图书馆和Scopus数据库，从其创建至2024年7月，查找涉及成年男性的随机对照试验（RCT）。这些研究的主要重点是生殖激素参数，采用随机效应荟萃分析和加权平均差（WMD）进行分析。使用ROB2和GRADE评估证据质量。进行了荟萃回归和剂量反应分析。
17项研究符合定量分析标准。补充维生素D显著提高了总睾酮水平（WMD 0.38，95%CI 0.06 - 0.70，n = 15，I = 67.03）。然而，它对其他激素参数没有显著影响：游离睾酮（WMD 0.00，95%CI -0.02 - 0.03，n = 9，I = 48.12）、FSH（WMD -0.02，95%CI -0.57 - 0.53，n = 7，I = 48.72）、LH（WMD -0.09，95%CI -0.30 - 0.12，n = 8，I = 0.00）、SHBG（WMD 0.73，95%CI -1.14 - 2.61，n = 10，I = 69.05）、FAI（WMD -0.92，95%CI -2.12 - 0.27，n = 6，I = 0.00）和雌二醇（WMD -0.02，95%CI -2.95 - 2.92，n = 5，I = 20.63）。
这项荟萃分析表明，补充维生素D可能会提高男性的总睾酮水平。然而，需要进一步设计良好的RCT来确定维生素D对其他生殖激素参数的影响。
