Bulog Aleksandar, Pavelic Kresimir, Šutić Ivana, Kraljevic Pavelic Sandra
Teaching Institute for Public Health of Primorsko-Goranska County, Krešimirova ulica 52, 51000 Rijeka, Croatia.
Faculty of Medicine, University of Rijeka, Braće Branchetta 20, 51000 Rijeka, Croatia.
J Funct Biomater. 2024 Oct 4;15(10):296. doi: 10.3390/jfb15100296.
Numerous scientific studies have been conducted in recent decades with the aim to study targeted application of zeolites in various industries, ecology, agronomy and medicine. The biggest advances, however, have been documented in medical and veterinary research of the natural zeolite, clinoptilolite. Although the exact biological mechanisms of action of the zeolite clinoptilolite are not completely elucidated, obtained results point to its antioxidative, immunomodulatory and detoxifying effects, the latter partially based on release of soluble and bioavailable silica forms from the surface material. The studied zeolite clinoptilolite materials have different geographical origins which confer to the physicochemical differences in the material. In addition, the production process of the material for oral applications differs between different producers which also accounts for different properties of the surface upon mechanical activation. Recently, a well-characterized zeolite clinoptilolite material, namely the PMA-zeolite, has been tested in different clinical applications and has shown potential as supportive therapy in inflammatory conditions, osteoporosis as well as during tumor chemotherapy. We accordingly present a comprehensive review of the PMA-zeolite effects in the clinical applications and discuss its probable mechanisms of effect in vivo.
近几十年来，人们进行了大量科学研究，旨在探索沸石在各个行业、生态、农学和医学中的靶向应用。然而，在天然沸石斜发沸石的医学和兽医学研究中取得了最大进展。尽管斜发沸石的确切生物学作用机制尚未完全阐明，但已获得的结果表明其具有抗氧化、免疫调节和解毒作用，后者部分基于从表面物质中释放出可溶且具有生物利用性的硅形式。所研究的斜发沸石材料有不同的地理来源，这导致了材料的物理化学差异。此外，不同生产商生产口服应用材料的过程也不同，这也导致了机械活化后材料表面性质的差异。最近，一种特性明确的斜发沸石材料，即PMA沸石，已在不同临床应用中进行了测试，并显示出在炎症性疾病、骨质疏松症以及肿瘤化疗期间作为支持性治疗的潜力。因此，我们对PMA沸石在临床应用中的作用进行了全面综述，并讨论了其在体内可能的作用机制。
