Ferreira Letícia do Nascimento Maximiano, Fisberg Regina Mara, Sarti Flavia Mori, Rogero Marcelo Macedo
Department of Nutrition, School of Public Health, University of São Paulo, 715 Dr. Arnaldo Avenue, São Paulo 01246-904, SP, Brazil.
School of Arts, Sciences and Humanities, University of São Paulo, 1000 Arlindo Bettio Avenue, São Paulo 03828-000, SP, Brazil.
Metabolites. 2024 Oct 5;14(10):535. doi: 10.3390/metabo14100535.
Recent studies suggest that plasma inflammatory biomarker concentrations may represent valuable indicators for the diagnosis and prognosis of mental disorders. At the same time, metabolic alterations may contribute to the development and progression of systemic low-grade inflammation. : This study evaluated the association between plasma inflammatory biomarkers and common mental disorders (CMD), exploring the relationship between metabolic biomarkers, metabolic syndrome (MetS), and inflammatory biomarkers in younger and older adults. : This cross-sectional study used data from the 2015 Health Survey of São Paulo with a Focus on Nutrition Study. The occurrence of CMD was assessed through the Self-Reporting Questionnaire (SRQ-20). Blood samples were used to measure plasma concentrations of inflammatory and cardiometabolic biomarkers. MetS was defined according to the International Diabetes Federation Consensus. The Mann-Whitney test compared inflammatory biomarker concentrations across CMD groups and cardiometabolic conditions, and logistic regression models explored associations between inflammatory biomarker concentration and CMD. : The sample included 575 participants, 22.6% (n = 130) of whom had CMD. Concentrations of plasminogen activator inhibitor 1, C-reactive protein (CRP), and the systemic low-grade inflammation score varied significantly among CMD groups. CRP concentrations were positively associated with the presence of CMD, independent of confounding factors. Participants with insulin resistance, dyslipidemia, and MetS exhibited significantly higher CRP concentrations than individuals without these conditions. : The findings suggest that increased plasma CRP concentrations may be a potential risk factor for CMD. Higher CRP concentrations were observed in individuals with insulin resistance, dyslipidemia, and MetS. Future interventional studies should explore these hypotheses in diverse populations.
近期研究表明，血浆炎症生物标志物浓度可能是精神障碍诊断和预后的重要指标。同时，代谢改变可能促使全身性低度炎症的发生和发展。本研究评估了血浆炎症生物标志物与常见精神障碍（CMD）之间的关联，探讨了年轻和老年人群中代谢生物标志物、代谢综合征（MetS）与炎症生物标志物之间的关系。本横断面研究使用了2015年圣保罗营养专项健康调查的数据。通过自填问卷（SRQ-20）评估CMD的发生情况。采集血样以测量炎症和心脏代谢生物标志物的血浆浓度。根据国际糖尿病联盟共识定义MetS。采用曼-惠特尼检验比较CMD组和心脏代谢状况之间的炎症生物标志物浓度，并通过逻辑回归模型探讨炎症生物标志物浓度与CMD之间的关联。样本包括575名参与者，其中22.6%（n = 130）患有CMD。纤溶酶原激活物抑制剂1、C反应蛋白（CRP）的浓度以及全身性低度炎症评分在CMD组之间存在显著差异。CRP浓度与CMD的存在呈正相关，不受混杂因素影响。患有胰岛素抵抗、血脂异常和MetS的参与者的CRP浓度显著高于未患这些疾病的个体。研究结果表明，血浆CRP浓度升高可能是CMD的潜在危险因素。在患有胰岛素抵抗、血脂异常和MetS的个体中观察到较高的CRP浓度。未来的干预研究应在不同人群中探索这些假设。
