2,2',4,4'-四溴二苯醚（BDE-47）对海洋生物的毒理学效应及作用机制
Toxicological Effects and Mechanisms of 2,2',4,4'-Tetrabromodiphenyl Ether (BDE-47) on Marine Organisms.
作者信息
Li Boyang, Shao Yun, Liu Chen, Wang Jie, Zhu Yanzhong, Li Xiaoqian
机构信息
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai 519000, China.
State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
出版信息
Toxics. 2024 Oct 15;12(10):747. doi: 10.3390/toxics12100747.
Abstract
2,2',4,4'-tetrabromodiphenyl ether (BDE-47) is a widely used brominated flame retardant belonging to persistent organic pollutants (POPs). After being released into the marine environment, BDE-47 can cause a range of toxic effects on marine organisms through bioaccumulation, biomagnification, and intergenerational transmission. These effects include lethality, impaired motility, photosynthetic toxicity, immune damage, liver toxicity, developmental impairments, and reproductive toxicity. This article reviews the latest research progress on the toxic effects and molecular mechanisms of BDE-47 mentioned above. The primary mechanisms underlying its toxicity include oxidative stress, DNA damage, cellular apoptosis, impaired metabolism, and activation of the MAPK signaling cascade.
摘要
2,2',4,4'-四溴二苯醚（BDE-47）是一种广泛使用的溴化阻燃剂，属于持久性有机污染物（POPs）。释放到海洋环境中后，BDE-47可通过生物累积、生物放大和代际传递对海洋生物造成一系列毒性影响。这些影响包括致死性、运动能力受损、光合毒性、免疫损伤、肝脏毒性、发育障碍和生殖毒性。本文综述了上述BDE-47毒性效应及分子机制的最新研究进展。其毒性的主要机制包括氧化应激、DNA损伤、细胞凋亡、代谢受损和MAPK信号级联激活。
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本文引用的文献
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Aquat Toxicol. 2024 Aug;273:106999. doi: 10.1016/j.aquatox.2024.106999. Epub 2024 Jun 10.
2
Molecular insight into the binding properties of marine algogenic dissolved organic matter for polybrominated diphenyl ethers and their combined effect on marine zooplankton.海洋源溶解性有机物与多溴二苯醚结合特性的分子洞察及其对海洋浮游动物的联合效应
Sci Total Environ. 2024 Apr 15;921:171131. doi: 10.1016/j.scitotenv.2024.171131. Epub 2024 Feb 21.
3
Natural and anthropogenic organic brominated compounds in the southwestern Atlantic ocean: Bioaccumulation in coastal and oceanic dolphin species.西南大西洋海域的天然和人为有机溴化化合物：沿海和海洋海豚物种的生物累积。
Environ Pollut. 2024 Jan 15;341:123005. doi: 10.1016/j.envpol.2023.123005. Epub 2023 Nov 21.
4
Metabolomic insights into neurological effects of BDE-47 exposure in the sea cucumber Apostichopus japonicus.代谢组学研究 BDE-47 暴露对海参神经系统影响的研究
Ecotoxicol Environ Saf. 2023 Nov 1;266:115558. doi: 10.1016/j.ecoenv.2023.115558. Epub 2023 Oct 10.
5
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Int J Mol Sci. 2023 Aug 12;24(16):12726. doi: 10.3390/ijms241612726.
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