Leone G, Sansonno D E, Manghisi O G
Minerva Med. 1986 Jan 28;77(3-4):113-8.
In order to report the eventual role of mastzellen in hepatic pathology, we recorded the histological count on 75 sections of transcutaneous hepatic biopsies. We observed that there is no difference between the number and the localization of the mastzellen of normal subjects and those of nonevolving pathologies (Chronic Persistent Hepatitis, Portal Fibrosis, Steatosis). We saw consisent increase in number in the evolving pathologies and in particular near the collagenopoietic cytolitic foci, indicating a possible role of these elements in inflammation and in the production of collagen in liver diseases.
为了报告肥大细胞在肝脏病理学中的最终作用,我们对75份经皮肝活检切片进行了组织学计数。我们观察到,正常受试者与非进行性病变(慢性持续性肝炎、门脉纤维化、脂肪变性)患者的肥大细胞数量和定位并无差异。我们发现,在进行性病变中,尤其是在胶原生成性细胞溶解灶附近,肥大细胞数量持续增加,这表明这些细胞在肝脏疾病的炎症反应及胶原蛋白生成过程中可能发挥作用。