School of Public Health, Capital Medical University, Beijing 100069, China.
Department of Atmospheric and Oceanic Science, Earth System Science Interdisciplinary Center, University of Maryland, College Park, MD 20740, USA.
J Hazard Mater. 2024 Dec 5;480:136212. doi: 10.1016/j.jhazmat.2024.136212. Epub 2024 Oct 18.
Ovarian aging, characterized by a decline in ovarian reserve, is a critical concern in female reproductive health. However, the evidence linking ambient air pollution exposure with ovarian reserve impairment remains limited. We aimed to estimate the association between exposure to fine particulate matter (PM) and respirable particulate matter (PM) and key indicators of ovarian reserve, including antral follicle count (AFC), ovarian volume (OV), anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), estradiol (E2), luteinizing hormone (LH), FSH/LH ratio, and inhibin B (INHB). The cohort consisted of women attending an infertility clinic at the Tongji Reproductive and Environmental (TREE) study between 2018 and 2020. We used multivariate linear and Poisson regression models to estimate the association between PM and PM exposure and these ovarian reserve indicators. Our results showed that PM and PM exposure were associated with a reduction in AFC and an increase in E2 levels, highlighting the adverse effects of ambient air pollution on ovarian reserve. Our findings have important public health implications, emphasizing the urgent need for interventions to safeguard female reproductive health and reduce exposure to ambient air pollution.
卵巢衰老，表现为卵巢储备功能下降，是女性生殖健康的一个关键问题。然而，环境空气污染暴露与卵巢储备损伤之间的关联证据仍然有限。我们旨在评估细颗粒物 (PM) 和可吸入颗粒物 (PM) 暴露与卵巢储备关键指标之间的关联，包括窦卵泡计数 (AFC)、卵巢体积 (OV)、抗苗勒管激素 (AMH)、促卵泡激素 (FSH)、雌二醇 (E2)、促黄体生成素 (LH)、FSH/LH 比值和抑制素 B (INHB)。该队列由 2018 年至 2020 年期间在同济生殖与环境 (TREE) 研究中就诊于不孕不育诊所的女性组成。我们使用多元线性和泊松回归模型来估计 PM 和 PM 暴露与这些卵巢储备指标之间的关联。我们的结果表明，PM 和 PM 暴露与 AFC 减少和 E2 水平升高有关，突出了环境空气污染对卵巢储备的不利影响。我们的研究结果具有重要的公共卫生意义，强调迫切需要采取干预措施来保护女性生殖健康并减少环境空气污染的暴露。
