Ageing Research Laboratories, Biosciences Institute, Faculty of Medical Sciences, Campus for Ageing and Health, Newcastle University, UK.
Ageing Res Rev. 2024 Dec;102:102558. doi: 10.1016/j.arr.2024.102558. Epub 2024 Oct 23.
Oxidative stress and cell senescence are both important drivers of ageing and age-associated disease and disability. In vitro, they are closely interconnected in a chicken-and-egg relationship: Not only is oxidative stress an important cause of cell senescence, but senescent cells are also sources of oxidative stress, obscuring cause-effect relationships during the ageing process. We hypothesize that cell senescence is a significant cause of tissue and systemic oxidative stress during ageing. This review aims to critically summarize the available evidence for this hypothesis. After summarizing the cellular feedback mechanisms that make oxidative stress an integral part of the senescent phenotype, it critically reviews the existing evidence for a role of senescent cells as causes of oxidative stress during mammalian ageing in vivo, focussing on results from intervention experiments. It is concluded that while the available data are in agreement with this hypothesis, they are still too scarce to support a robust conclusion.
氧化应激和细胞衰老都是衰老和与年龄相关的疾病和残疾的重要驱动因素。在体外，它们以一种鸡生蛋、蛋生鸡的关系密切相关：氧化应激不仅是细胞衰老的重要原因，衰老细胞也是氧化应激的来源，这使得衰老过程中的因果关系变得模糊。我们假设细胞衰老在衰老过程中是组织和全身氧化应激的一个重要原因。本综述旨在批判性地总结这一假说的现有证据。在总结了使氧化应激成为衰老表型固有部分的细胞反馈机制之后，本文批判性地回顾了衰老细胞作为哺乳动物体内衰老过程中氧化应激原因的现有证据，重点关注干预实验的结果。结论是，尽管现有数据与这一假说一致，但它们仍然太少，无法得出有力的结论。
