一名患有巨人症的男性的泌乳素分泌型垂体腺瘤：病例报告
Prolactin-secreting pituitary adenoma in a man with gigantism: a case report.
作者信息
Peillon F, Philippon J, Brandi A M, Fohanno D, Laplane D, Dubois M P, Decourt J
出版信息
Acta Endocrinol (Copenh). 1979 Dec;92(4):627-39. doi: 10.1530/acta.0.0920627.
A prolactin-secreting pituitary adenoma was removed trans-sphenoidally from a 37 years old man with gigantism (218 cm). Serum levels of prolactin (PRL) were elevated pre-operatively and decreased after administration of L-Dopa with no increase after TRH as is usually observed in PRL-secreting adenomas. Growth hormone (GH) and somatomedin serum levels were normal with no modification of GH after insulin hypoglycemia, oral glucose loading or L-Dopa. Morphological examination of the tumour demonstrated the presence of lactotrophs by light and electron microscopy and by immunofluorescense staining. No somatotrophs were found. In this unique case, the relationship between a PRL-secreting adenoma and gigantism is discussed.
一名患有巨人症（身高218厘米）的37岁男性经蝶窦切除了分泌催乳素的垂体腺瘤。术前血清催乳素（PRL）水平升高，给予左旋多巴后下降，促甲状腺激素释放激素（TRH）刺激后未如分泌PRL腺瘤通常所见那样升高。生长激素（GH）和生长介素血清水平正常，胰岛素低血糖、口服葡萄糖负荷或左旋多巴刺激后GH无变化。肿瘤的形态学检查通过光镜、电镜及免疫荧光染色显示有催乳素细胞。未发现生长激素细胞。在这个独特的病例中，讨论了分泌PRL腺瘤与巨人症之间的关系。
Zotero 插件