State Key Laboratory of Quality Research in Chinese Medicine, Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease, Macau Institute for Applied Research in Medicine and Health, Faculty of Chinese Medicine, Macau University of Science and Technology, Macau 999078, China.
Biomolecules. 2024 Sep 24;14(10):1202. doi: 10.3390/biom14101202.
Lactate accumulation and macrophage infiltration are pivotal features of both chronic inflammation and cancer. Lactate, once regarded merely as an aftereffect of glucose metabolism, is now gaining recognition for its burgeoning spectrum of biological roles and immunomodulatory significance. Recent studies have evidenced that macrophages display divergent immunophenotypes in different diseases, which play a pivotal role in disease management by modulating macrophage polarization within the disease microenvironment. The specific polarization patterns of macrophages in a high-lactate environment and their contribution to the progression of chronic inflammation and cancer remain contentious. This review presents current evidence on the crosstalk of lactate and macrophage in chronic inflammation and cancer. Additionally, we provide an in-depth exploration of the pivotal yet enigmatic mechanisms through which lactate orchestrates disease pathogenesis, thereby offering novel perspectives to the development of targeted therapeutic interventions for chronic inflammation and cancer.
乳酸积累和巨噬细胞浸润是慢性炎症和癌症的两个关键特征。乳酸曾被仅仅视为葡萄糖代谢的一种副产物，而现在由于其不断涌现的生物学作用和免疫调节意义而受到重视。最近的研究表明，巨噬细胞在不同疾病中表现出不同的免疫表型，通过调节疾病微环境中的巨噬细胞极化，在疾病管理中发挥关键作用。在高乳酸环境中巨噬细胞的特定极化模式及其对慢性炎症和癌症进展的贡献仍存在争议。本综述介绍了乳酸与慢性炎症和癌症中巨噬细胞相互作用的最新证据。此外，我们深入探讨了乳酸协调疾病发病机制的关键而神秘的机制，为慢性炎症和癌症的靶向治疗干预措施的发展提供了新的视角。
