First Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, Stilponos Kyriakidi 1, 54636 Thessaloniki, Greece.
Department of Neurology, University Hospital of Larissa, School of Medicine, University of Thessaly, 41100 Larissa, Greece.
Biomolecules. 2024 Sep 26;14(10):1213. doi: 10.3390/biom14101213.
While there is a link between homocysteine (Hcy), B12 and folic acid and neurodegeneration, especially in disorders like Parkinson's and Alzheimer's diseases, its role in Parkinson plus syndromes (PPS) has only been partially investigated. It appears that elevated Hcy, along with an imbalance of its essential vitamin cofactors, are both implicated in the development and progression of parkinsonian syndromes, which represent different disease pathologies, namely alpha-synucleinopathies and tauopathies. Attributing a potential pathogenetic role in hyperhomocysteinemia would be crucial in terms of improving the diagnostic and prognostic accuracy of these syndromes and also for providing a new target for possible therapeutic intervention. The scope of this review is to focus on vitamin imbalance in PPS, with a special emphasis on the role of Hcy, B12 and folic acid in the neurodegenerative process and their implication in the therapeutic approach of these disorders.
虽然同型半胱氨酸（Hcy）、B12 和叶酸与神经退行性变之间存在关联，尤其是在帕金森病和阿尔茨海默病等疾病中，但它在帕金森叠加综合征（PPS）中的作用仅部分得到了研究。似乎升高的 Hcy 及其必需维生素辅因子的失衡都与帕金森综合征的发展和进展有关，这些综合征代表了不同的疾病病理学，即α-突触核蛋白病和tau 病。在高同型半胱氨酸血症中归因于潜在的发病机制作用，对于提高这些综合征的诊断和预后准确性以及为可能的治疗干预提供新的靶点将是至关重要的。这篇综述的范围是关注 PPS 中的维生素失衡，特别强调 Hcy、B12 和叶酸在神经退行性过程中的作用及其在这些疾病的治疗方法中的意义。
