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心血管疾病中的糖鞘脂：从分子机制和心力衰竭模型中获得的见解。

Glycosphingolipids in Cardiovascular Disease: Insights from Molecular Mechanisms and Heart Failure Models.

机构信息

Department of Medicine, Division of Cardiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA.

Department of Surgery, Virginia Tech Carilion School of Medicine, Roanoke, VA 24061, USA.

出版信息

Biomolecules. 2024 Oct 8;14(10):1265. doi: 10.3390/biom14101265.

DOI:10.3390/biom14101265
PMID:39456198
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11506000/
Abstract

This review explores the crucial role of glycosphingolipids (GSLs) in the context of cardiovascular diseases (CVDs), focusing on their biosynthesis, metabolic pathways, and implications for clinical outcomes. GSLs are pivotal in regulating a myriad of cellular functions that are essential for heart health and disease progression. Highlighting findings from both human cohorts and animal models, this review emphasizes the potential of GSLs as biomarkers and therapeutic targets. We advocate for more detailed mechanistic studies to deepen our understanding of GSL functions in cardiovascular health, which could lead to innovative strategies for diagnosis, treatment, and personalized medicine in cardiovascular care.

摘要

这篇综述探讨了糖脂（GSLs）在心血管疾病（CVDs）中的关键作用，重点关注其生物合成、代谢途径以及对临床结果的影响。GSLs 在调节多种细胞功能方面发挥着关键作用，这些功能对于心脏健康和疾病进展至关重要。本综述强调了 GSL 作为生物标志物和治疗靶点的潜力，引用了来自人类队列和动物模型的研究结果。我们主张进行更详细的机制研究，以加深我们对 GSL 在心血管健康中的功能的理解，这可能为心血管护理中的诊断、治疗和个性化医学提供创新策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e3d/11506000/e7cec716c0e3/biomolecules-14-01265-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e3d/11506000/39f51e70caa9/biomolecules-14-01265-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e3d/11506000/934569e771bc/biomolecules-14-01265-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e3d/11506000/0bdf4c2a4c20/biomolecules-14-01265-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e3d/11506000/e7cec716c0e3/biomolecules-14-01265-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e3d/11506000/39f51e70caa9/biomolecules-14-01265-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e3d/11506000/934569e771bc/biomolecules-14-01265-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e3d/11506000/0bdf4c2a4c20/biomolecules-14-01265-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e3d/11506000/e7cec716c0e3/biomolecules-14-01265-g004.jpg

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