State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430072, China.
Department of Endodontics, School & Hospital of Stomatology, Wuhan University, Wuhan 430072, China.
Biomolecules. 2024 Oct 17;14(10):1319. doi: 10.3390/biom14101319.
N6-methyladenosine (mA), the most abundant RNA modification in eukaryotes, has a crucial impact on tumorigenesis. KIAA1429 is the key component of the mA methyltransferase complex, in which KIAA1429 functions as a scaffold to bridge the catalytic core proteins. KIAA1429 is often overexpressed in malignances, associated with patient prognosis, and required for tumorigenesis. KIAA1429 regulates the expression of a number of tumor-associated genes in an mA -dependent manner, and thus, contributes to cell proliferation, migration, drug resistance, tumor formation and metastasis. This review focuses on recent progress in the understanding of roles and mechanisms of KIAA1429 in cancers, and offers ideas for potential anti-cancer therapeutic methods by targeting KIAA1429.
N6-甲基腺苷（mA）是真核生物中最丰富的 RNA 修饰物，对肿瘤发生有重要影响。KIAA1429 是 mA 甲基转移酶复合物的关键组成部分，其中 KIAA1429 作为支架，连接催化核心蛋白。KIAA1429 在恶性肿瘤中常过度表达，与患者预后相关，并且是肿瘤发生所必需的。KIAA1429 以 mA 依赖性方式调节许多与肿瘤相关基因的表达，从而促进细胞增殖、迁移、耐药、肿瘤形成和转移。本综述重点介绍了近年来对 KIAA1429 在癌症中的作用和机制的理解进展，并提供了通过靶向 KIAA1429 作为潜在的抗癌治疗方法的思路。
