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植物疗法对牙周炎中NRF2/KEAP1信号通路的调节作用

Modulation of NRF2/KEAP1 Signaling by Phytotherapeutics in Periodontitis.

作者信息

Tossetta Giovanni, Fantone Sonia, Togni Lucrezia, Santarelli Andrea, Olivieri Fabiola, Marzioni Daniela, Rippo Maria Rita

机构信息

Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, 60126 Ancona, Italy.

Scientific Direction, IRCCS INRCA, 60124 Ancona, Italy.

出版信息

Antioxidants (Basel). 2024 Oct 18;13(10):1270. doi: 10.3390/antiox13101270.

DOI:10.3390/antiox13101270
PMID:39456522
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11504014/
Abstract

Periodontitis affects up to 40% of adults over 60 years old and is a consequence of gingivitis. Periodontitis is characterized by a chronic inflammation, periodontal damage, and alveolar bone resorption. The nuclear factor erythroid 2-related factor 2 (NFE2L2 or NRF2)/Kelch-like ECH-Associated Protein 1 (KEAP1) (NRF2/KEAP1) signaling pathway plays a key role in periodontitis by modulating redox balance and inflammation of the periodontium. However, NRF2 expression is decreased in gingival tissues of patients with periodontitis while oxidative stress is significantly increased in this pathology. Oxidative stress and lipopolysaccharide (LPS) produced by gram-negative bacteria favor the production of inflammatory causing periodontal inflammation and favoring alveolar bone. In this review, we analyzed the current literature regarding the role of natural and synthetic compounds in modulating the NRF2/KEAP1 pathway in in vitro and in vivo models of periodontitis in order to evaluate new potential treatments of periodontitis that can improve the outcome of this disease.

摘要

牙周炎影响着高达40%的60岁以上成年人，是牙龈炎的后果。牙周炎的特征是慢性炎症、牙周组织损伤和牙槽骨吸收。核因子红细胞2相关因子2（NFE2L2或NRF2）/ Kelch样ECH相关蛋白1（KEAP1）（NRF2/KEAP1）信号通路通过调节牙周组织的氧化还原平衡和炎症，在牙周炎中起关键作用。然而，牙周炎患者牙龈组织中的NRF2表达降低，而在这种病理状态下氧化应激显著增加。革兰氏阴性菌产生的氧化应激和脂多糖（LPS）促进炎症产生，导致牙周炎症并促进牙槽骨吸收。在这篇综述中，我们分析了当前关于天然和合成化合物在体外和体内牙周炎模型中调节NRF2/KEAP1通路作用的文献，以评估可以改善该疾病治疗效果的牙周炎新潜在治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778c/11504014/c36022b2418d/antioxidants-13-01270-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778c/11504014/2d3204729408/antioxidants-13-01270-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778c/11504014/4b13f2e0dbe8/antioxidants-13-01270-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778c/11504014/641a7500d6d8/antioxidants-13-01270-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778c/11504014/8c78429a3ad0/antioxidants-13-01270-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778c/11504014/c36022b2418d/antioxidants-13-01270-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778c/11504014/2d3204729408/antioxidants-13-01270-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778c/11504014/4b13f2e0dbe8/antioxidants-13-01270-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778c/11504014/641a7500d6d8/antioxidants-13-01270-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778c/11504014/8c78429a3ad0/antioxidants-13-01270-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/778c/11504014/c36022b2418d/antioxidants-13-01270-g005.jpg

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