The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 5290002, Israel.
Advanced Materials and Nanotechnology Institute, Bar-Ilan University, Ramat Gan 5290002, Israel.
Int J Mol Sci. 2024 Oct 19;25(20):11268. doi: 10.3390/ijms252011268.
The UL24 protein family, conserved across all subfamilies of Orthoherpesviridae, plays diverse and significant roles in viral replication, host-virus interactions and pathogenesis. Understanding the molecular mechanisms and interactions of UL24 proteins is key to unraveling the complex interplay between herpesviruses and their hosts. This review provides a comparative and comprehensive overview of current knowledge on UL24 family members, including their conservation, expression patterns, cellular localization, and functional roles upon their expression and during viral infection, highlighting their significance in herpesvirus biology and their potential functions.
UL24 蛋白家族在疱疹病毒科的所有亚科中都保守存在，在病毒复制、宿主-病毒相互作用和发病机制中发挥着多样化且重要的作用。了解 UL24 蛋白的分子机制和相互作用是揭示疱疹病毒与其宿主之间复杂相互作用的关键。本文对 UL24 家族成员的现有知识进行了比较和全面的综述，包括它们的保守性、表达模式、细胞定位以及在表达和病毒感染过程中的功能作用，突出了它们在疱疹病毒生物学中的重要性及其潜在功能。
