Mandrell Belinda N, Guo Yian, Li Yimei, Hancock Donna, Caples Mary, Ashford Jason M, Merchant Thomas E, Conklin Heather M, Crabtree Valerie Mc
Department of Pediatric Medicine and Division of Nursing Research, St. Jude Children's Research Hospital, Memphis, TN 38501, USA.
Statistician Sutter Health Care, Palo Alto, CA 94301, USA.
Children (Basel). 2024 Sep 25;11(10):1159. doi: 10.3390/children11101159.
The aim of this study was to describe fatigue, health-related quality of life (HRQOL) and brain tumor-associated symptoms after surgical resection and during proton radiotherapy, using latent class analysis (LCA), and to determine if there is class membership change among pediatric patients with craniopharyngioma.
For all patients ( = 92), demographic and disease-related/clinical variables were attained, and patient reported outcomes were collected prior to proton therapy, at week three, and at the completion of proton therapy. The mean scores for fatigue, HRQOL, and brain tumor symptoms were compared over time and profiles were identified. Factors that influenced profile status and transition probability were examined.
Fatigue, HRQOL, and brain tumor symptoms improved over time during proton therapy; however, a subset remained in the lower profile, profile 1, associated with increased internalizing behaviors, compared to profile 2.
Future study should explore the bidirectional relationship of sleep, worry and anxiety in the context of ongoing radiotherapy.
本研究旨在利用潜在类别分析（LCA）描述手术切除后及质子放疗期间的疲劳、健康相关生活质量（HRQOL）和脑肿瘤相关症状，并确定颅咽管瘤患儿患者的类别归属是否发生变化。
对所有患者（n = 92）获取人口统计学和疾病相关/临床变量，并在质子治疗前、第三周和质子治疗完成时收集患者报告的结局。比较不同时间点疲劳、HRQOL和脑肿瘤症状的平均得分并确定概况。检查影响概况状态和转变概率的因素。
在质子治疗期间，疲劳、HRQOL和脑肿瘤症状随时间改善；然而，与概况2相比，有一部分患者仍处于较低概况，即概况1，与内化行为增加有关。
未来研究应在正在进行的放疗背景下探索睡眠、担忧和焦虑的双向关系。
