Patel Ami, Nguyen Lannhi, Shea Christina, Singh Sunjum, Venketaraman Vishwanath
College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
Biomedicines. 2024 Oct 1;12(10):2238. doi: 10.3390/biomedicines12102238.
: () is a pathogen that causes tuberculosis (TB), an extremely infectious disease which is responsible for millions of deaths worldwide. The severity of this pathogen is further amplified with the emergence of multidrug-resistant strains that are becoming more prevalent at an alarming rate, and novel treatments are needed. : In this paper, we discuss the pathology infection. We review the literature on the role that mTOR plays in autophagy and the immune system as well as its impact on infection. Lastly, we discuss the current therapies targeting mTOR and potential routes to explore for future treatments. : The mTOR protein acts as a negative regulator of the autophagy pathway and presents as a potent target to establish new treatments for TB. survival is affected by mTOR, the PI3K/mTOR/AKT pathway, and autophagy. evades destruction by manipulating host cellular mechanisms, which increases resistance and complicates treatment. : Targeting mTOR can enhance autophagy and increase clearance. Existing drugs such as everolimus, rapamycin + CC214-2, and bazedoxifene are all being currently studied for effectiveness and show positive results. Alternative therapies, including Chinese herbs, baicalin, BTLA, glutathione, and precision medicine can modulate the PI3K/mTOR/AKT pathway and the host's immune response, resulting in increased clearance, and these may be the future treatments for infection.
（结核分枝杆菌）是一种导致结核病（TB）的病原体，结核病是一种极具传染性的疾病，在全球造成数百万人死亡。随着多重耐药菌株以惊人的速度日益普遍出现，这种病原体的严重性进一步加剧，因此需要新的治疗方法。在本文中，我们讨论了（结核分枝杆菌）感染的病理学。我们回顾了关于mTOR在自噬和免疫系统中的作用及其对（结核分枝杆菌）感染影响的文献。最后，我们讨论了目前针对mTOR的疗法以及未来治疗可探索的潜在途径。mTOR蛋白作为自噬途径的负调节因子，是建立结核病新治疗方法的有力靶点。（结核分枝杆菌）的存活受mTOR、PI3K/mTOR/AKT途径和自噬的影响。（结核分枝杆菌）通过操纵宿主细胞机制逃避破坏，这增加了耐药性并使治疗复杂化。靶向mTOR可以增强自噬并增加（结核分枝杆菌）的清除。目前正在研究现有药物如依维莫司、雷帕霉素+CC214-2和巴泽昔芬的有效性，并显示出积极结果。替代疗法，包括中草药、黄芩苷、BTLA、谷胱甘肽和精准医学，可以调节PI3K/mTOR/AKT途径和宿主的免疫反应，从而增加（结核分枝杆菌）的清除，这些可能是未来治疗（结核分枝杆菌）感染的方法。
