Nguyen Kevin H, Alcantara Cheldon Ann, Glassman Ira, May Nicole, Mundra Akaash, Mukundan Abinanda, Urness Bianca, Yoon Sonyeol, Sakaki Roajhaan, Dayal Surbi, Chowdhury Tanzila, Harshavardhan Shakila, Ramanathan Vadakupattu, Venketaraman Vishwanath
Department of Basic Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
Department of Molecular Microbiology, Madurai Kamaraj University, Tamil Nadu 625021, India.
Pathogens. 2023 Jul 8;12(7):920. doi: 10.3390/pathogens12070920.
Tuberculosis is an ancient disease that humanity struggled with for centuries and continues to struggle with. The bacteria often infects the lungs through respiratory transmission and manifests itself through various symptoms, including cutaneous infections. Cutaneous tuberculosis (CTB) comprises about 1% to 1.5% of all extrapulmonary manifestations and is often accompanied by polymorphous lesions, including papules, nodules, plaques, ulcers, gummas, and verrucous lesions. CTB is most commonly observed in low-income, HIV, and immunosuppressed populations, similar to intrapulmonary manifestations. The main pathogen for CTB is but less commonly with and BCG vaccine, and the modes of transmission are largely classified into exogenous and endogenous CTB. Current treatment options for CTB include oral therapy of antibiotic medications such as rifampicin, streptomycin, ethambutol, isoniazid, and pyrazinamide, which is occasionally combined with surgical intervention.
结核病是一种古老的疾病,人类与之抗争了几个世纪,并且仍在继续抗争。这种细菌通常通过呼吸道传播感染肺部,并通过各种症状表现出来,包括皮肤感染。皮肤结核病(CTB)约占所有肺外表现的1%至1.5%,常伴有多形性病变,包括丘疹、结节、斑块、溃疡、树胶肿和疣状病变。与肺内表现相似,CTB最常见于低收入、艾滋病毒感染和免疫抑制人群。CTB的主要病原体是 但较少见的是 和卡介苗,传播方式主要分为外源性和内源性CTB。目前CTB的治疗选择包括口服抗生素药物,如利福平、链霉素、乙胺丁醇、异烟肼和吡嗪酰胺,偶尔还会结合手术干预。