Paiva Mariana Sousa, Santos Rita Reis, Guerreiro Sara, Ribeiras Regina
Cardiology Department, Hospital de Santa Cruz, Unidade Local de Saúde de Lisboa Ocidental, Carnaxide, 2790-134 Lisbon, Portugal.
Cardiology Department, Hospital dos Lusíadas, 1500-458 Lisbon, Portugal.
Biomedicines. 2024 Oct 3;12(10):2249. doi: 10.3390/biomedicines12102249.
In recent decades, a burgeoning interest in tricuspid regurgitation (TR) has been prompted by a heightened awareness of its prevalence and the advent of dedicated percutaneous treatment approaches. Despite considerable understanding of its intricate anatomy and response to varying pressure and loading conditions, the impact of biological sex remains a subject of investigation. While TR typically afflicts more women, significant differences in TR etiology and post-treatment outcomes have not been conclusively established. This narrative review seeks to consolidate the latest evidence concerning sex-related nuances in anatomy, pathophysiology, diagnosis, treatment, and prognosis of significant tricuspid regurgitation. Through synthesizing this information, we aim to provide a comprehensive understanding of how sex may influence the management and prognosis of this condition.
近几十年来，对三尖瓣反流（TR）的兴趣迅速增长，这是由于人们对其患病率的认识提高以及专用经皮治疗方法的出现。尽管对其复杂的解剖结构以及对不同压力和负荷条件的反应有了相当的了解，但生物性别的影响仍是一个研究课题。虽然TR通常在女性中更为常见，但TR病因和治疗后结果的显著差异尚未得到最终确定。这篇叙述性综述旨在整合有关严重三尖瓣反流在解剖学、病理生理学、诊断、治疗和预后方面与性别相关细微差别的最新证据。通过综合这些信息，我们旨在全面了解性别如何影响这种疾病的管理和预后。
