探索新冠康复者端粒长度与认知变化之间的关系。
Exploring the Relationship between Telomere Length and Cognitive Changes in Post-COVID-19 Subjects.
作者信息
Villar-Juárez Guillermo Efrén, Genis-Mendoza Alma Delia, Martínez-López J Nicolas I, Fresan Ana, Tovilla-Zaráte Carlos Alfonso, Nolasco-Rosales German Alberto, Juárez-De la Cruz Ghandy Isidro, Ramos David Ruiz, Villar-Soto Mario, Mejía-Ortiz Paola, Gómez Mendiola Marlen, Juárez-Rojop Isela Esther, Nicolini Humberto
机构信息
Escuela de Medicina, Universidad Anáhuac Querétaro, Querétaro 76246, Mexico.
Instituto Nacional de Medicina Genómica, Secretaría de Salud, Mexico City 14610, Mexico.
出版信息
Biomedicines. 2024 Oct 10;12(10):2296. doi: 10.3390/biomedicines12102296.
BACKGROUND/OBJECTIVES: Emerging evidence suggests that patients suffering from COVID-19 may experience neurocognitive symptoms. Furthermore, other studies indicate a probable association between leukocyte telomere length (LTL) and neurocognitive changes in subjects with post-COVID-19 condition. Our study was designed to determine the correlation between telomere length and cognitive changes in post-COVID-19 subjects.
METHODS
This study included 256 subjects, categorized based on SARS-CoV-2 infection from 2020 to 2023. In addition, subjects with a psychiatric diagnosis were considered. Moreover, the MoCA and MMSE scales were applied. Telomere length was determined using a polymerase chain reaction, and statistical analysis was employed using ANOVA and X tests.
RESULTS
We identified a decrease in LTL in individuals with post-COVID-19 conditions compared to those without SARS-CoV-2 infection ( ≤ 0.05). However, no association was found between LTL and cognitive impairment in the subjects post-COVID-19.
CONCLUSIONS
The findings suggest that LTL is affected by SARS-CoV-2 infection. Nonetheless, this important finding requires further research by monitoring neurological changes in subjects with post-COVID condition.
背景/目的：新出现的证据表明，感染新型冠状病毒肺炎（COVID-19）的患者可能会出现神经认知症状。此外，其他研究表明，白细胞端粒长度（LTL）与COVID-19康复者的神经认知变化之间可能存在关联。我们的研究旨在确定COVID-19康复者的端粒长度与认知变化之间的相关性。
方法
本研究纳入了256名受试者，根据2020年至2023年期间的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染情况进行分类。此外，还考虑了有精神疾病诊断的受试者。此外，应用了蒙特利尔认知评估量表（MoCA）和简易精神状态检查表（MMSE）。使用聚合酶链反应测定端粒长度，并采用方差分析（ANOVA）和X检验进行统计分析。
结果
我们发现，与未感染SARS-CoV-2的个体相比，COVID-19康复者的LTL有所下降（P≤0.05）。然而，在COVID-19康复者中，未发现LTL与认知障碍之间存在关联。
结论
研究结果表明，LTL受SARS-CoV-2感染的影响。尽管如此，这一重要发现需要通过监测COVID-19康复者的神经变化进行进一步研究。
Zotero 插件