Villar-Juárez Guillermo Efrén, Genis-Mendoza Alma Delia, Martínez-López J Nicolas I, Fresan Ana, Tovilla-Zaráte Carlos Alfonso, Nolasco-Rosales German Alberto, Juárez-De la Cruz Ghandy Isidro, Ramos David Ruiz, Villar-Soto Mario, Mejía-Ortiz Paola, Gómez Mendiola Marlen, Juárez-Rojop Isela Esther, Nicolini Humberto
Escuela de Medicina, Universidad Anáhuac Querétaro, Querétaro 76246, Mexico.
Instituto Nacional de Medicina Genómica, Secretaría de Salud, Mexico City 14610, Mexico.
Biomedicines. 2024 Oct 10;12(10):2296. doi: 10.3390/biomedicines12102296.
BACKGROUND/OBJECTIVES: Emerging evidence suggests that patients suffering from COVID-19 may experience neurocognitive symptoms. Furthermore, other studies indicate a probable association between leukocyte telomere length (LTL) and neurocognitive changes in subjects with post-COVID-19 condition. Our study was designed to determine the correlation between telomere length and cognitive changes in post-COVID-19 subjects.
This study included 256 subjects, categorized based on SARS-CoV-2 infection from 2020 to 2023. In addition, subjects with a psychiatric diagnosis were considered. Moreover, the MoCA and MMSE scales were applied. Telomere length was determined using a polymerase chain reaction, and statistical analysis was employed using ANOVA and X tests.
We identified a decrease in LTL in individuals with post-COVID-19 conditions compared to those without SARS-CoV-2 infection ( ≤ 0.05). However, no association was found between LTL and cognitive impairment in the subjects post-COVID-19.
The findings suggest that LTL is affected by SARS-CoV-2 infection. Nonetheless, this important finding requires further research by monitoring neurological changes in subjects with post-COVID condition.
背景/目的：新出现的证据表明，感染新型冠状病毒肺炎（COVID-19）的患者可能会出现神经认知症状。此外，其他研究表明，白细胞端粒长度（LTL）与COVID-19康复者的神经认知变化之间可能存在关联。我们的研究旨在确定COVID-19康复者的端粒长度与认知变化之间的相关性。
本研究纳入了256名受试者，根据2020年至2023年期间的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染情况进行分类。此外，还考虑了有精神疾病诊断的受试者。此外，应用了蒙特利尔认知评估量表（MoCA）和简易精神状态检查表（MMSE）。使用聚合酶链反应测定端粒长度，并采用方差分析（ANOVA）和X检验进行统计分析。
我们发现，与未感染SARS-CoV-2的个体相比，COVID-19康复者的LTL有所下降（P≤0.05）。然而，在COVID-19康复者中，未发现LTL与认知障碍之间存在关联。
研究结果表明，LTL受SARS-CoV-2感染的影响。尽管如此，这一重要发现需要通过监测COVID-19康复者的神经变化进行进一步研究。
