Maktabi Briana, Collins Abigail, Safee Raihaanah, Bouyer Jada, Wisner Alexander S, Williams Frederick E, Schiefer Isaac T
Department of Pharmacology and Experimental Therapeutics, University of Toledo, Toledo, OH 43614, USA.
Center for Drug Design and Development 3, University of Toledo, Toledo, OH 43614, USA.
Biomedicines. 2024 Oct 16;12(10):2354. doi: 10.3390/biomedicines12102354.
Zebrafish have become a key model organism in neuroscience research because of their unique advantages. Their genetic, anatomical, and physiological similarities to humans, coupled with their rapid development and transparent embryos, make them an excellent tool for investigating various aspects of neurobiology. They have specifically emerged as a valuable and versatile model organism in biomedical research, including the study of neurological disorders such as multiple sclerosis. Multiple sclerosis is a chronic autoimmune disease known to cause damage to the myelin sheath that protects the nerves in the brain and spinal cord. This review emphasizes the importance of continued research in both in vitro and in vivo models to advance our understanding of MS and develop effective treatments, ultimately improving the quality of life for those affected by this debilitating disease. Recent studies show the significance of zebrafish as a model organism for investigating demyelination and remyelination processes, providing new insights into MS pathology and potential therapies.
由于其独特的优势，斑马鱼已成为神经科学研究中的关键模式生物。它们在基因、解剖学和生理学上与人类相似，再加上其发育迅速且胚胎透明，使其成为研究神经生物学各个方面的优秀工具。它们尤其已成为生物医学研究中有价值且通用的模式生物，包括对诸如多发性硬化症等神经系统疾病的研究。多发性硬化症是一种慢性自身免疫性疾病，已知会对保护大脑和脊髓神经的髓鞘造成损害。 本综述强调了在体外和体内模型中持续开展研究对于增进我们对多发性硬化症的理解并开发有效治疗方法的重要性，最终改善受这种使人衰弱疾病影响者的生活质量。 最近的研究表明斑马鱼作为研究脱髓鞘和髓鞘再生过程的模式生物的重要性，为多发性硬化症病理学和潜在疗法提供了新的见解。
