Rajewski Paweł, Pawłowska Małgorzata, Kozielewicz Dorota, Dybowska Dorota, Olczak Anita, Cieściński Jakub
Department of Internal and Infectious Diseases, Provincial Infectious Disease Hospital, 85-030 Bydgoszcz, Poland.
Faculty of Health Sciences, University of Health Sciences in Bydgoszcz, 85-067 Bydgoszcz, Poland.
Biomedicines. 2024 Oct 20;12(10):2400. doi: 10.3390/biomedicines12102400.
: Cardiovascular diseases are one of the leading causes of hospitalization and death in Poland and around the world and are still an ongoing problem for modern medicine. Despite advances in diagnosis and treatment, both conservative and invasive, the prevention of cardiovascular disease directed at reducing risk factors remains a problem. The main classical risk factors for the development of cardiovascular disease in Poland include hypertension, lipid disorders, obesity, diabetes and smoking. A new non-classical risk factor is HCV infection. Most of the studies on the impact of HCV infection on cardiovascular disease involve elderly populations with long-term infections and advanced liver fibrosis. : Hence, we set out to analyze the prevalence of risk factors and cardiovascular disease in a population of young adults under 45 years of age infected with HCV, according to gender, HCV genotype and the duration of infection. The study group consisted of 217 patients of both sexes aged 21 to 45 years (mean age 36 years). : No cardiovascular disease was found among the young adults infected with HCV in the study group. The most common risk factor was cigarette smoking, which affected 20.7% of the subjects, followed by hypertension (12%) and diabetes mellitus (5.5%); the prevalence was lower than in the general population. Most of the patients were characterized as overweight, with a mean BMI of 26.39 kg/m. The mean values of other metabolic parameters-total cholesterol, LDL, HDL, uric acid and glucose-were within the population norm. The mean value of CRP was 1.43, which may indicate a moderate cardiovascular risk. : Based on the conducted research, it was found that HCV infection in young individuals was not a risk factor for cardiovascular diseases, and the prevalence of risk factors was similar to that in the general population. The effect of HCV on the increase in C-reactive protein requires further study. The early detection of HCV infection and treatment can be considered as a prevention of cardiovascular disease.
心血管疾病是波兰乃至全球住院和死亡的主要原因之一，仍然是现代医学面临的一个持续存在的问题。尽管在诊断和治疗方面取得了进展，包括保守治疗和侵入性治疗，但针对降低风险因素的心血管疾病预防仍然是一个问题。波兰心血管疾病发展的主要经典风险因素包括高血压、脂质紊乱、肥胖、糖尿病和吸烟。一个新的非经典风险因素是丙型肝炎病毒（HCV）感染。大多数关于HCV感染对心血管疾病影响的研究都涉及长期感染和晚期肝纤维化的老年人群。因此，我们着手分析45岁以下感染HCV的年轻人群中风险因素和心血管疾病的患病率，根据性别、HCV基因型和感染持续时间进行分析。研究组由217名年龄在21至45岁之间的男女患者组成（平均年龄36岁）。研究组中感染HCV的年轻成年人未发现心血管疾病。最常见的风险因素是吸烟，影响了20.7%的受试者，其次是高血压（12%）和糖尿病（5.5%）；其患病率低于一般人群。大多数患者被归类为超重，平均体重指数（BMI）为26.39kg/m。其他代谢参数——总胆固醇、低密度脂蛋白、高密度脂蛋白、尿酸和葡萄糖的平均值在人群正常范围内。C反应蛋白（CRP）的平均值为1.43，这可能表明存在中度心血管风险。基于所进行的研究，发现年轻个体中的HCV感染不是心血管疾病的风险因素，风险因素的患病率与一般人群相似。HCV对C反应蛋白升高的影响需要进一步研究。HCV感染的早期检测和治疗可被视为预防心血管疾病的一种方法。
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