Fazio Serafino, Bellavite Paolo, Affuso Flora
School of Medicine, Federico II University, 80100 Naples, Italy.
Homeopatic Medical School of Verona, 37121 Verona, Italy.
Biomedicines. 2024 Oct 21;12(10):2416. doi: 10.3390/biomedicines12102416.
Despite all the progress made by science in the prevention and treatment of cardiovascular diseases and cancers, these are still the main reasons for hospitalizations and death in the Western world. Among the possible causes of this situation, disorders related to hyperinsulinemia and insulin resistance (Hyperin/IR) are still little-known topics. An analysis of the literature shows that this condition is a multiple risk factor for type 2 diabetes, cardiovascular diseases, cellular senescence and cancer, and neurodegenerative diseases. Hyperin/IR is progressively increasing worldwide, and its prevalence has now exceeded 50% of the general population and in overweight children. Asymptomatic or poorly symptomatic, it can last for many years before manifesting itself as diabetes, cardiovascular disease, neoplasm, cognitive deficit, or dementia, therefore leading to enormous social and healthcare costs. For these reasons, a screening plan for this pathology should be implemented for the purpose of identifying people with Hyperin/IR and promptly starting them on preventive treatment.
尽管科学在心血管疾病和癌症的预防与治疗方面取得了诸多进展，但这些疾病仍是西方世界住院和死亡的主要原因。在造成这种情况的可能原因中，与高胰岛素血症和胰岛素抵抗（Hyperin/IR）相关的病症仍是鲜为人知的话题。文献分析表明，这种情况是2型糖尿病、心血管疾病、细胞衰老、癌症以及神经退行性疾病的多重风险因素。Hyperin/IR在全球范围内呈逐渐上升趋势，其患病率现已超过普通人群的50%，在超重儿童中亦是如此。由于它通常无症状或症状不明显，可能会持续多年才表现为糖尿病、心血管疾病、肿瘤、认知缺陷或痴呆，从而导致巨大的社会和医疗成本。基于这些原因，应实施针对这种病症的筛查计划，以识别患有Hyperin/IR的人群，并及时让他们开始接受预防性治疗。
