Małkiewicz Marta A, Malinowski Krzysztof S, Grzywińska Małgorzata, Partinen Eemil, Partinen Markku, Pyrzowski Jan, Wszędybył-Winklewska Magdalena
Applied Cognitive Neuroscience Lab, Department of Neurophysiology, Neuropsychology and Neuroinformatics, Medical University of Gdansk, 80-210 Gdansk, Poland.
Department of Neurophysiology, Neuropsychology and Neuroinformatics, Medical University of Gdansk, 80-210 Gdansk, Poland.
J Clin Med. 2024 Oct 14;13(20):6129. doi: 10.3390/jcm13206129.
Periodic limb movements in sleep (PLMS) are a prevalent disorder characterized by rhythmic, involuntary movements of the lower limbs, such as dorsiflexion of the ankle and extension of the big toe, occurring in periodic intervals during sleep. These movements are often linked to disrupted autonomic nervous system (ANS) activity and altered interoception. Interoception involves perceiving internal bodily states, like heartbeat, breathing, hunger, and temperature, and plays a crucial role in maintaining homeostasis and the mind-body connection. This review explores the complex relationships between PLMS, heart rate variability (HRV), ANS dysregulation, and their impact on psychiatric disorders. By synthesizing the existing literature, it provides insights into how ANS dysregulation and altered interoceptive processes, alongside PLMS, contribute to psychiatric conditions. The review highlights the potential for integrated diagnostic and therapeutic approaches and presents a cause-and-effect model illustrating the mutual influence of psychiatric disorders, ANS dysregulation, PLMS, and interoception.
睡眠期周期性肢体运动（PLMS）是一种常见的疾病，其特征是下肢有节律的、不自主的运动，如脚踝背屈和大脚趾伸展，在睡眠期间周期性出现。这些运动通常与自主神经系统（ANS）活动紊乱和内感受改变有关。内感受涉及感知身体内部状态，如心跳、呼吸、饥饿和体温，并在维持体内平衡和身心联系方面发挥关键作用。本综述探讨了PLMS、心率变异性（HRV）、ANS失调之间的复杂关系，以及它们对精神疾病的影响。通过综合现有文献，本综述深入探讨了ANS失调和内感受过程改变如何与PLMS一起导致精神疾病。该综述强调了综合诊断和治疗方法的潜力，并提出了一个因果模型，阐明了精神疾病、ANS失调、PLMS和内感受之间的相互影响。
