Department of Pharmacology, School of Medicine, Ningbo University, 818 Fenghua Rd., Ningbo 315211, China.
Department of Pharmacy, Zhejiang Pharmaceutical University, 666 Siming Rd., Ningbo 315211, China.
Molecules. 2024 Oct 14;29(20):4872. doi: 10.3390/molecules29204872.
Liver disease is a global public problem, and the cost of its therapy is a large financial burden to governments. It is well known that drug therapy plays a critical role in the treatment of liver disease. However, present drugs are far from meeting clinical needs. Lots of efforts have been made to find novel agents to treat liver disease in the past several decades. Acacetin is a dihydroxy and monomethoxy flavone, named 5,7-dihydroxy-4'-methoxyflavone, which can be found in diverse plants. It has been reported that acacetin exhibits multiple pharmacological activities, including anti-cancer, anti-inflammation, anti-virus, anti-obesity, and anti-oxidation. These studies indicate the therapeutic potential of acacetin in liver disease. This review discussed the comprehensive information on the pathogenesis of liver disease (cirrhosis, viral hepatitis, drug-induced liver injury, and hepatocellular carcinoma), then introduced the biological source, structural features, and pharmacological properties of acacetin, and the possible application in preventing liver disease along with the pharmacokinetic and toxicity of acacetin, and future research directions. We systemically summarized the latest research progress on the potential therapeutic effect of acacetin on liver disease and existing problems. Based on the present published information, the natural flavone acacetin is an anticipated candidate agent for the treatment of liver disease.
肝脏疾病是一个全球性的公共卫生问题，其治疗费用给各国政府带来了巨大的财政负担。众所周知，药物治疗在肝脏疾病的治疗中起着至关重要的作用。然而，现有的药物远不能满足临床需求。在过去的几十年里，人们做出了许多努力来寻找治疗肝脏疾病的新型药物。 芹黄素是一种二羟基和单甲氧基黄酮，命名为 5,7-二羟基-4'-甲氧基黄酮，可在多种植物中找到。据报道，芹黄素具有多种药理活性，包括抗癌、抗炎、抗病毒、抗肥胖和抗氧化作用。这些研究表明芹黄素在肝脏疾病中的治疗潜力。 本综述讨论了肝脏疾病（肝硬化、病毒性肝炎、药物性肝损伤和肝细胞癌）发病机制的综合信息，然后介绍了芹黄素的生物来源、结构特征和药理学特性，以及预防肝脏疾病的可能应用，以及芹黄素的药代动力学和毒性，以及未来的研究方向。我们系统地总结了芹黄素对肝脏疾病潜在治疗作用的最新研究进展和存在的问题。基于目前已发表的信息，天然类黄酮芹黄素是治疗肝脏疾病的一种有希望的候选药物。
