Students' Research Club, Department of Clinical Pharmacology, Medical University of Lodz, 90-153 Lodz, Poland.
Department of Clinical Electrocardiology, Medical University of Lodz, 92-213 Lodz, Poland.
Int J Mol Sci. 2023 Jun 2;24(11):9677. doi: 10.3390/ijms24119677.
The prevalence of metabolic-related disorders, such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (DM2), has been increasing. Therefore, developing improved methods for the prevention, treatment, and detection of these two conditions is also necessary. In this study, our primary focus was on examining the role of chronic inflammation as a potential link in the pathogenesis of these diseases and their interconnections. A comprehensive search of the PubMed database using keywords such as "non-alcoholic fatty liver disease", "type 2 diabetes mellitus", "chronic inflammation", "pathogenesis", and "progression" yielded 177 relevant papers for our analysis. The findings of our study revealed intricate relationships between the pathogenesis of NAFLD and DM2, emphasizing the crucial role of inflammatory processes. These connections involve various molecular functions, including altered signaling pathways, patterns of gene methylation, the expression of related peptides, and up- and downregulation of several genes. Our study is a foundational platform for future research into the intricate relationship between NAFLD and DM2, allowing for a better understanding of the underlying mechanisms and the potential for introducing new treatment standards.
代谢相关疾病的患病率不断上升，如非酒精性脂肪性肝病（NAFLD）和 2 型糖尿病（DM2）。因此，开发预防、治疗和检测这两种疾病的改良方法也是必要的。在这项研究中，我们主要关注慢性炎症作为这些疾病发病机制及其相互关联的潜在联系的作用。使用“非酒精性脂肪性肝病”、“2 型糖尿病”、“慢性炎症”、“发病机制”和“进展”等关键词，对 PubMed 数据库进行全面检索，共获得 177 篇相关论文进行分析。我们的研究结果揭示了 NAFLD 和 DM2 发病机制之间的复杂关系，强调了炎症过程的关键作用。这些联系涉及各种分子功能，包括信号通路改变、基因甲基化模式、相关肽的表达以及多个基因的上调和下调。我们的研究为 NAFLD 和 DM2 之间复杂关系的未来研究提供了一个基础平台，有助于更好地理解潜在机制，并有可能引入新的治疗标准。
