Faculty of Chemical Sciences, Autonomous University of San Luis Potosi, Dr. Manuel Nava Martínez Avenue #6, University Zone, San Luis Potosi 78210, Mexico.
Faculty of Nursing and Nutrition, Autonomous University of San Luis Potosi, Niño Artillero Avenue #130, University Zone, San Luis Potosi 78240, Mexico.
Molecules. 2024 Oct 20;29(20):4958. doi: 10.3390/molecules29204958.
Snow mountain garlic is traditionally eaten by Himalayan locals for its medicinal properties. Although different species of the genus are known to have other biological effects, such as antiplatelet and antithrombotic activities, little is known about the anticoagulant effect of Snow mountain garlic, a member of the genus . Therefore, the present study examined the anticoagulant effect of the aqueous extract, the lyophilized aqueous extract, and the isoflavone extract from the lyophilized aqueous extract of Snow mountain garlic in samples from 50 human blood donors. Compared to the control, concentrations of 25, 12.5, and 6.25 mg/100 µL lengthened the clotting times of prothrombin, and concentrations of 25 and 12.5 mg/100 µL lengthened the activated partial thromboplastin time ( ˂ 0.05). The isoflavone extract from the lyophilized aqueous extract containing isoflavones, organosulfur compounds, a polyphenol, and a steroid glycoside showed a significant effect ( ˂ 0.05) on the prothrombin time and the activated partial thromboplastin time at a dose of 20 µL (volume) compared to the control. The results regarding the use of Snow mountain garlic as a preventive measure and aid in treating thromboembolic disease are promising.
雪山大蒜因其药用特性而被喜马拉雅地区的当地人传统食用。尽管已知该属的不同物种具有其他生物学作用，如抗血小板和抗血栓形成活性，但对于雪山大蒜（该属的一种）的抗凝作用知之甚少。因此，本研究在 50 名献血者的样本中检测了雪山大蒜水提物、冻干水提物及其冻干水提物中异黄酮提取物的抗凝作用。与对照组相比，浓度为 25、12.5 和 6.25 mg/100 µL 的凝血酶原时间延长，浓度为 25 和 12.5 mg/100 µL 的活化部分凝血活酶时间延长（ ˂ 0.05）。含异黄酮、有机硫化合物、多酚和甾体糖苷的冻干水提物的异黄酮提取物在 20 µL（体积）剂量下对凝血酶原时间和活化部分凝血活酶时间的影响与对照组相比具有显著作用（ ˂ 0.05）。使用雪山大蒜作为预防和辅助治疗血栓栓塞性疾病的措施的结果很有前景。
