First Department of Orthopedic Surgery, School of Medicine, National and Kapodistrian University of Athens, "ATTIKON" University General Hospital, 12462 Athens, Greece.
Medicina (Kaunas). 2024 Oct 12;60(10):1675. doi: 10.3390/medicina60101675.
: Tenosynovial giant cell tumor (TGCT) is a rare, locally aggressive, benign neoplasm arising from the synovium of joints, tendon sheaths, and bursa. There are two main subtypes of TGCT: localized-type TGCT(L-TGCT) and diffuse-type TGCT (D-TGCT). While surgical excision is still considered the gold standard of treatment, the high recurrence rate, especially for D-TGCT, may suggest the need for other treatment modalities. : This study reviews current literature on the current treatment modalities for refractory-relapsed TGCT disease. : The gold standard of treatment modality in TGCT remains surgical excision of the tumor nevertheless, the elevated recurrence rate and refractory disease, particularly in D-TGCT indicates and underscores the necessity for additional treatment alternatives. : TGCT is a benign tumor with inflammatory features and a potential destructive and aggressive course that can lead to significant morbidity and functional impairment with a high impact on quality of life. Surgical resection remains the gold standard current treatment and the optimal surgical approach depends on the location and extent of the tumor. Systemic therapies have been recently used for relapsed mainly cases.
: 腱鞘巨细胞瘤（TGCT）是一种罕见的、局部侵袭性的良性肿瘤，起源于关节、腱鞘和滑囊的滑膜。TGCT 有两种主要亚型：局限性腱鞘巨细胞瘤（L-TGCT）和弥漫性腱鞘巨细胞瘤（D-TGCT）。虽然手术切除仍然被认为是治疗的金标准，但高复发率，特别是 D-TGCT，可能表明需要其他治疗方法。: 本研究回顾了目前关于复发性 TGCT 疾病的治疗方法的文献。: 在 TGCT 中，治疗方法的金标准仍然是手术切除肿瘤，然而，高复发率和难治性疾病，特别是 D-TGCT，表明需要额外的治疗选择。: TGCT 是一种具有炎症特征的良性肿瘤，具有潜在的破坏性和侵袭性，可能导致严重的发病率和功能障碍，对生活质量有重大影响。手术切除仍然是目前的金标准治疗方法，最佳的手术方法取决于肿瘤的位置和范围。系统治疗最近已被用于治疗主要的复发病例。
