Cerović Kosta, Hadžialjević Benjamin, Hawlina Simon, Trotovšek Blaž
Clinical Department of Urology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.
Department of Surgery, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.
Life (Basel). 2024 Oct 17;14(10):1319. doi: 10.3390/life14101319.
Combined liver-kidney transplantation (CLKT) has evolved as a therapeutic option for patients with concurrent end-stage liver and renal diseases. This study evaluates the perioperative and long-term outcomes of CLKT at a single center in Slovenia, highlighting the challenges and successes of simultaneous organ transplantation. We retrospectively analyzed all patients undergoing simultaneous CLKT at the University Medical Centre Ljubljana from April 2014 to June 2023. Data on demographics, cause of liver and kidney disease, operative details, postoperative complications, patient and graft survival, and follow-up were collected and analyzed. Five patients aged 27 to 60 years underwent CLKT within the study period. All transplants involved deceased donors with whole-liver grafts. Indications for CLKT were polycystic liver disease ( = 3), Caroli's disease ( = 1), and alcoholic cirrhosis ( = 1). The mean follow-up duration was 45.2 months, with a 100% survival rate. The incidence of surgical and postoperative complications was low. This pioneering series of simultaneous CLKTs in Slovenia demonstrates the feasibility and effectiveness of the procedure in smaller transplant centers. Despite challenges, including T cell-mediated kidney rejection and surgical complications, the study emphasizes the importance of comprehensive postoperative care and management in optimizing outcomes for CLKT recipients.
肝肾联合移植（CLKT）已发展成为终末期肝病和肾病并发患者的一种治疗选择。本研究评估了斯洛文尼亚一家单一中心的肝肾联合移植围手术期和长期结果，突出了同时进行器官移植的挑战与成功之处。我们回顾性分析了2014年4月至2023年6月在卢布尔雅那大学医学中心接受同期肝肾联合移植的所有患者。收集并分析了有关人口统计学、肝脏和肾脏疾病病因、手术细节、术后并发症、患者和移植物存活情况以及随访的数据。在研究期间，5名年龄在27至60岁之间的患者接受了肝肾联合移植。所有移植均采用来自脑死亡供体的全肝移植物。肝肾联合移植的适应症为多囊肝（n = 3）、卡罗利病（n = 1）和酒精性肝硬化（n = 1）。平均随访时间为45.2个月，存活率为100%。手术和术后并发症的发生率较低。斯洛文尼亚这一系列开创性的同期肝肾联合移植证明了该手术在较小移植中心的可行性和有效性。尽管存在挑战，包括T细胞介导的肾脏排斥反应和手术并发症，但该研究强调了全面术后护理和管理对优化肝肾联合移植受者结局的重要性。
