Nakagawa Y, Kinomoto H, Abe H
Stroke. 1986 Jan-Feb;17(1):25-30. doi: 10.1161/01.str.17.1.25.
Effects of intravenous infusion of dopamine on local cortical blood flow (CBF) and somatosensory evoked potentials (SEP) was evaluated using canine cerebral ischemia, which was produced by middle cerebral artery occlusion. CBF was monitored with a H2 clearance method and SEP. P1 to N1 peak to peak amplitude (V1) was recorded by stimulating the sciatic nerve on the contralateral side. CBF and SEP recovered at doses of 5 and 10 gamma, despite almost no increase of systemic arterial pressure. CBF and SEP were restored at doses of dopamine of 20 and 30 gamma, with an increase of mean systemic arterial pressure 5 to 15 mm Hg and similar results were obtained at doses of 25 gamma. Recovery of SEP was slight at extremely high doses of dopamine (65 gamma), despite a definite increase of mean systemic arterial pressure (MSAP) and CBF.
利用大脑中动脉闭塞所导致的犬脑缺血模型，评估静脉输注多巴胺对局部皮质血流量（CBF）和体感诱发电位（SEP）的影响。采用氢气清除法和SEP监测CBF。通过刺激对侧坐骨神经记录P1至N1峰峰值幅度（V1）。尽管全身动脉压几乎没有升高，但在5和10微克剂量时CBF和SEP恢复。在20和30微克多巴胺剂量时CBF和SEP恢复，同时平均全身动脉压升高5至15毫米汞柱，25微克剂量时获得类似结果。在极高剂量多巴胺（65微克）时SEP恢复轻微，尽管平均动脉压（MSAP）和CBF有明显升高。
