• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

IFITM3 的生物学功能研究进展。

Research Progress into the Biological Functions of IFITM3.

机构信息

School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-Sen University, Shenzhen 518107, China.

Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

出版信息

Viruses. 2024 Sep 29;16(10):1543. doi: 10.3390/v16101543.

DOI:10.3390/v16101543
PMID:39459876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11512382/
Abstract

Interferon-induced transmembrane proteins (IFITMs) are upregulated by interferons. They are not only highly conserved in evolution but also structurally consistent and have almost identical structural domains and functional domains. They are all transmembrane proteins and have multiple heritable variations in genes. The IFITM protein family is closely related to a variety of biological functions, including antiviral immunity, tumor formation, bone metabolism, cell adhesion, differentiation, and intracellular signal transduction. The progress of the research on its structure and related functions, as represented by IFITM3, is reviewed.

摘要

干扰素诱导跨膜蛋白（IFITMs）受干扰素诱导而上调。它们在进化上不仅高度保守，而且结构一致，具有几乎相同的结构域和功能域。它们都是跨膜蛋白，基因中有多种遗传性变异。IFITM 蛋白家族与多种生物学功能密切相关，包括抗病毒免疫、肿瘤形成、骨代谢、细胞黏附、分化和细胞内信号转导。以 IFITM3 为代表，综述了其结构和相关功能研究的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa8/11512382/c113be9de656/viruses-16-01543-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa8/11512382/6912ab81f566/viruses-16-01543-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa8/11512382/1af89692cfa2/viruses-16-01543-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa8/11512382/5ebe3239fbfd/viruses-16-01543-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa8/11512382/6340635d64c0/viruses-16-01543-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa8/11512382/58b15dfdae6b/viruses-16-01543-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa8/11512382/c113be9de656/viruses-16-01543-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa8/11512382/6912ab81f566/viruses-16-01543-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa8/11512382/1af89692cfa2/viruses-16-01543-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa8/11512382/5ebe3239fbfd/viruses-16-01543-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa8/11512382/6340635d64c0/viruses-16-01543-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa8/11512382/58b15dfdae6b/viruses-16-01543-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa8/11512382/c113be9de656/viruses-16-01543-g006.jpg

相似文献

1
Research Progress into the Biological Functions of IFITM3.IFITM3 的生物学功能研究进展。
Viruses. 2024 Sep 29;16(10):1543. doi: 10.3390/v16101543.
2
Functional Mapping of Regions Involved in the Negative Imprinting of Virion Particle Infectivity and in Target Cell Protection by Interferon-Induced Transmembrane Protein 3 against HIV-1.抗病毒蛋白诱导跨膜蛋白 3 对 HIV-1 病毒粒子感染性的负印迹作用及对靶细胞保护作用相关区域的功能图谱。
J Virol. 2019 Jan 4;93(2). doi: 10.1128/JVI.01716-18. Print 2019 Jan 15.
3
Duck Interferon-Inducible Transmembrane Protein 3 Mediates Restriction of Influenza Viruses.鸭干扰素诱导跨膜蛋白3介导对流感病毒的限制。
J Virol. 2015 Oct 14;90(1):103-16. doi: 10.1128/JVI.01593-15. Print 2016 Jan 1.
4
Identification of differentially expressed transcripts targeted by the knockdown of endogenous IFITM3.内源性IFITM3敲低靶向的差异表达转录本的鉴定
Mol Med Rep. 2016 Nov;14(5):4367-4373. doi: 10.3892/mmr.2016.5777. Epub 2016 Sep 26.
5
IFITM Proteins That Restrict the Early Stages of Respiratory Virus Infection Do Not Influence Late-Stage Replication.IFITM 蛋白限制呼吸道病毒感染的早期阶段，但不影响晚期复制。
J Virol. 2021 Sep 27;95(20):e0083721. doi: 10.1128/JVI.00837-21. Epub 2021 Jul 28.
6
pH Optimum of Hemagglutinin-Mediated Membrane Fusion Determines Sensitivity of Influenza A Viruses to the Interferon-Induced Antiviral State and IFITMs.血凝素介导的膜融合的最适pH值决定甲型流感病毒对干扰素诱导的抗病毒状态和干扰素诱导跨膜蛋白的敏感性。
J Virol. 2017 May 12;91(11). doi: 10.1128/JVI.00246-17. Print 2017 Jun 1.
7
Identification of Residues Controlling Restriction versus Enhancing Activities of IFITM Proteins on Entry of Human Coronaviruses.确定控制IFITM蛋白对人冠状病毒进入的限制与增强活性的残基。
J Virol. 2018 Feb 26;92(6). doi: 10.1128/JVI.01535-17. Print 2018 Mar 15.
8
Bat and pig IFN-induced transmembrane protein 3 restrict cell entry by influenza virus and lyssaviruses.蝙蝠和猪的干扰素诱导跨膜蛋白3可限制流感病毒和狂犬病病毒的细胞进入。
J Gen Virol. 2015 May;96(Pt 5):991-1005. doi: 10.1099/vir.0.000058. Epub 2015 Jan 22.
9
Long Noncoding RNA IFITM4P Regulates Host Antiviral Responses by Acting as a Competing Endogenous RNA.长链非编码 RNA IFITM4P 通过作为竞争性内源性 RNA 调节宿主抗病毒反应。
J Virol. 2021 Oct 13;95(21):e0027721. doi: 10.1128/JVI.00277-21. Epub 2021 Jul 21.
10
The palmitoyltransferase ZDHHC20 enhances interferon-induced transmembrane protein 3 (IFITM3) palmitoylation and antiviral activity.棕榈酰转移酶 ZDHHC20 增强干扰素诱导的跨膜蛋白 3（IFITM3）棕榈酰化和抗病毒活性。
J Biol Chem. 2017 Dec 29;292(52):21517-21526. doi: 10.1074/jbc.M117.800482. Epub 2017 Oct 27.

引用本文的文献

1
Ubiquitin E3 ligase MARCH10 targets influenza hemagglutinin for ubiquitination.泛素E3连接酶MARCH10将流感血凝素作为泛素化的靶标。
Cell Signal. 2025 Jul 30;135:112035. doi: 10.1016/j.cellsig.2025.112035.
2
Identification and validation of tissue-based gene biomarkers for acute intestinal graft-versus-host disease(AIGVHD).急性肠道移植物抗宿主病（AIGVHD）基于组织的基因生物标志物的鉴定与验证。
Front Immunol. 2025 May 13;16:1574904. doi: 10.3389/fimmu.2025.1574904. eCollection 2025.

本文引用的文献

1
FOXP3 regulatory T cell perturbation mediated by the IFNγ-STAT1-IFITM3 feedback loop is essential for anti-tumor immunity.干扰素 γ-STAT1-IFITM3 反馈回路介导的 FOXP3 调节性 T 细胞扰动对于抗肿瘤免疫至关重要。
Nat Commun. 2024 Jan 2;15(1):122. doi: 10.1038/s41467-023-44391-9.
2
Long-Read Sequencing Reveals Rapid Evolution of Immunity- and Cancer-Related Genes in Bats.长读测序揭示了蝙蝠中与免疫和癌症相关基因的快速进化。
Genome Biol Evol. 2023 Sep 4;15(9). doi: 10.1093/gbe/evad148.
3
The truncated IFITM3 facilitates the humoral immune response in inactivated influenza vaccine-vaccinated mice via interaction with CD81.
截短的 IFITM3 通过与 CD81 相互作用，促进了灭活流感疫苗免疫接种小鼠的体液免疫反应。
Emerg Microbes Infect. 2023 Dec;12(2):2246599. doi: 10.1080/22221751.2023.2246599.
4
IFITM2 Presents Antiviral Response through Enhancing Type I IFN Signaling Pathway.IFITM2 通过增强 I 型 IFN 信号通路发挥抗病毒作用。
Viruses. 2023 Mar 28;15(4):866. doi: 10.3390/v15040866.
5
Interferon-inducible phospholipids govern IFITM3-dependent endosomal antiviral immunity.干扰素诱导磷脂调控 IFITM3 依赖的内体抗病毒免疫。
EMBO J. 2023 May 15;42(10):e112234. doi: 10.15252/embj.2022112234. Epub 2023 Mar 27.
6
IFITM protein regulation and functions: Far beyond the fight against viruses.IFITM 蛋白的调控与功能：远不止对抗病毒那么简单。
Front Immunol. 2022 Nov 18;13:1042368. doi: 10.3389/fimmu.2022.1042368. eCollection 2022.
7
IFITM proteins: Understanding their diverse roles in viral infection, cancer, and immunity.IFITM 蛋白：解析其在病毒感染、癌症和免疫中的多样角色。
J Biol Chem. 2023 Jan;299(1):102741. doi: 10.1016/j.jbc.2022.102741. Epub 2022 Nov 23.
8
IFITM3 Inhibits SARS-CoV-2 Infection and Is Associated with COVID-19 Susceptibility.IFITM3 抑制 SARS-CoV-2 感染，并与 COVID-19 易感性相关。
Viruses. 2022 Nov 18;14(11):2553. doi: 10.3390/v14112553.
9
Expression and mechanisms of interferon-stimulated genes in viral infection of the central nervous system (CNS) and neurological diseases.干扰素刺激基因在中枢神经系统（CNS）病毒感染和神经疾病中的表达和机制。
Front Immunol. 2022 Oct 17;13:1008072. doi: 10.3389/fimmu.2022.1008072. eCollection 2022.
10
IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses.IFITM3 通过限制 Nogo-B 介导的 TLR 反应来限制病毒诱导的炎症细胞因子产生。
Nat Commun. 2022 Sep 8;13(1):5294. doi: 10.1038/s41467-022-32587-4.