大鼠蛛网膜下腔出血：对中枢5-羟色胺能和多巴胺能系统损伤所致脑血管痉挛发展的影响
Subarachnoid haemorrhage in the rat: effect on the development of cerebral vasospasm of lesions in the central serotoninergic and dopaminergic systems.
作者信息
Svendgaard N A, Brismar J, Delgado T J, Rosengren E, Stenevi U
出版信息
Stroke. 1986 Jan-Feb;17(1):86-90. doi: 10.1161/01.str.17.1.86.
PMID:3945990
Abstract
In the rat an intracisternal injection of blood induces an angiographically demonstrable biphasic cerebral arterial vasospasm. Chemical destruction of the central serotoninergic and dopaminergic pathways prior to the cisternal blood injection does not affect the spasm pattern after the subarachnoid haemorrhage. It is suggested that neither system plays a role in the development of spasm.
摘要
在大鼠中，脑池内注射血液可诱发血管造影显示的双相性脑动脉血管痉挛。在脑池内注射血液之前，对中枢5-羟色胺能和多巴胺能通路进行化学破坏，并不影响蛛网膜下腔出血后的痉挛模式。这表明这两个系统在痉挛的发生过程中均不起作用。
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