Graduate School of Science and Technology, Shizuoka University, 3-5-1 Johoku, Naka-ku, Hamama-tsu-shi 432-8561, Japan.
tst Biomedical Electronics Co., Ltd., Taoyuan 324403, Taiwan.
Sensors (Basel). 2024 Oct 10;24(20):6517. doi: 10.3390/s24206517.
Cardiovascular disease (CVD) represents the leading cause of death worldwide. For individuals at elevated risk for cardiovascular disease, early detection and monitoring of lipid status is imperative. The majority of lipid measurements conducted in hospital settings employ optical detection, which necessitates the use of relatively large-sized detection machines. It is, therefore, necessary to develop point-of-care testing (POCT) for lipoprotein in order to monitor CVD. To enhance the management and surveillance of CVD, this study sought to develop a POCT approach for apolipoprotein B (ApoB) utilizing a shear horizontal surface acoustic wave (SH-SAW) platform to assess the risk of heart disease. The platform employs a reflective SH-SAW sensor to reduce the sensor size and enhance the phase-shifted signals. In this study, the platform was utilized to monitor the impact of a weekly almond and oat milk or statins intervention on alterations in CVD risk. The SH-SAW ApoB test exhibited a linear range of 0 to 212 mg/dL, and a coefficient correlation (R) of 0.9912. Following a four-week intervention period, both the almond and oat milk intervention (-23.3%, < 0.05) and statin treatment (-53.1%, < 0.01) were observed to significantly reduce ApoB levels. These findings suggest that the SH-SAW POCT device may prove a valuable tool for monitoring CVD risk, particularly during routine daily or weekly follow-up visits.
心血管疾病（CVD）是全球范围内的主要致死原因。对于心血管疾病风险较高的个体，早期检测和监测脂质状况至关重要。大多数在医院环境中进行的脂质测量采用光学检测，这需要使用相对较大尺寸的检测机器。因此，为了监测 CVD，有必要开发用于脂蛋白的即时检测（POCT）。为了增强 CVD 的管理和监测，本研究旨在开发一种利用剪切水平表面声波（SH-SAW）平台评估心脏病风险的载脂蛋白 B（ApoB）POCT 方法。该平台采用反射式 SH-SAW 传感器来减小传感器尺寸并增强相移信号。在本研究中，该平台用于监测每周杏仁和燕麦奶或他汀类药物干预对 CVD 风险变化的影响。SH-SAW ApoB 测试的线性范围为 0 至 212mg/dL，相关系数（R）为 0.9912。经过四周的干预期后，杏仁和燕麦奶干预（-23.3%，<0.05）和他汀类药物治疗（-53.1%，<0.01）均显著降低了 ApoB 水平。这些发现表明，SH-SAW POCT 设备可能成为监测 CVD 风险的有用工具，特别是在日常或每周的常规随访就诊期间。
