Hutson D H, Logan C J
Xenobiotica. 1986 Jan;16(1):87-93. doi: 10.3109/00498258609043509.
A good inverse correlation between the acute oral toxicity of chlorfenvinphos and its rate of oxidative detoxification in the liver exists for rats, mice, rabbits and dogs. Measurements of the rates of oxidative metabolism (O-de-ethylation) by in vitro liver preparations from rat, rabbit and human have been compared. When the results are expressed in terms of cytochrome P450, as opposed to microsomal protein, detoxification by the human liver enzyme(s) is almost as effective as that by rabbit enzyme(s). The rabbit is relatively resistant to the acute toxic action of the insecticide.
对于大鼠、小鼠、兔子和狗而言，毒虫畏的急性经口毒性与其在肝脏中的氧化解毒速率之间存在良好的负相关关系。已比较了来自大鼠、兔子和人类的体外肝脏制剂的氧化代谢速率（O-脱乙基化）的测量结果。当结果以细胞色素P450表示时，与微粒体蛋白相反，人肝酶的解毒效果几乎与兔酶一样有效。兔子对该杀虫剂的急性毒性作用相对具有抗性。
