Departamento de Ginecologia, Escola Paulista de Medicina/Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, SP, Brasil.
Departamento de Ginecologia, Escola Paulista de Medicina/Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, SP, Brasil.
Clinics (Sao Paulo). 2024 Oct 25;79:100506. doi: 10.1016/j.clinsp.2024.100506. eCollection 2024.
According to growing evidence, sleep disruption harms biological processes and circadian homeostasis. Diurnal motor symptom volatility in Parkinson's Disease (PD) has been extensively studied. Few studies examined seasonal variability in PD symptoms, some showing it and others not.
To investigate whether PD patients' deaths follow a rhythmic pattern due to circadian rhythm alterations.
This study used only unidentified patient databases. People with PD, ICD10 code G20, in at least one death certificate field were selected. The Continuous Wavelet Transform and Fourier Transform were checked for oscillation and its duration.
The 18-year analysis found 43,072 PD deaths. The Continuous Wavelet transform revealed a 351.87-day annual component (p < 0.05). Winter in the southern hemisphere saw more deaths, mainly in July. The Continuous Wavelet transform identified a significant daily component (p < 0.05) of 22.81 hours. Fatalities peaked around 9 a.m. Pneumonia is the leading cause of death in PD, and women and men have the same rhythm pattern.
Parkinson's disease mortality in Brazil follows a pattern. Using over 40.000 death certificates from 18 years, the authors found that Parkinson's patient fatalities rise in winter and peak in July at about 9 a.m. Sunlight reduction increases mortality risk in the long term. Low sunshine lowers temperatures, increasing short-term death risk. This is crucial because it prioritizes the sun, seasons, and circadian rhythm over low temperatures.
越来越多的证据表明，睡眠紊乱会损害生物过程和昼夜节律的稳态。帕金森病（PD）的日间运动症状波动性已得到广泛研究。少数研究检查了 PD 症状的季节性变化，有些显示存在变化，有些则没有。
研究 PD 患者的死亡是否因昼夜节律改变而呈现节律性模式。
本研究仅使用未识别的患者数据库。选择至少在一份死亡证明字段中具有 PD（ICD10 代码 G20）的患者。检查了连续小波变换和傅里叶变换是否存在振荡及其持续时间。
18 年的分析发现了 43072 例 PD 死亡。连续小波变换显示出 351.87 天的年度分量（p<0.05）。南半球的冬季死亡人数更多，主要集中在 7 月。连续小波变换确定了一个显著的每日分量（p<0.05），为 22.81 小时。死亡高峰出现在上午 9 点左右。肺炎是 PD 的主要死因，女性和男性的节律模式相同。
巴西帕金森病的死亡率呈现一定模式。通过使用 18 年来超过 40000 份死亡证明，作者发现帕金森病患者的死亡率在冬季上升，并在 7 月左右上午 9 点达到高峰。阳光减少会增加长期死亡风险。阳光不足会降低温度，增加短期死亡风险。这一点至关重要，因为它将阳光、季节和昼夜节律置于低温之上。
