Clinical Medical Research Center for Women and Children Diseases, Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan 250001, China; School of Public Health, Qingdao University, Qingdao 266071, China.
School of Public Health, North China University of Science and Technology, Tangshan 063000, China.
Ecotoxicol Environ Saf. 2024 Nov 1;286:117245. doi: 10.1016/j.ecoenv.2024.117245. Epub 2024 Oct 25.
A growing body of evidence exhibits the ubiquitous presence and accumulation of micro- and nanoplastics (MNPs) in the air, drinking water, food, and even inside the body, which has raised concerns about their potential impact on reproductive and developmental health. To comprehensively examine the current state of knowledge regarding MNPs-induced reproductive and developmental toxicity, we conducted this systematic review by focusing on the prevalence of MNPs determined in reproductive tissues and their influences on parental reproduction and offspring development. Our findings demonstrate the detection of MNPs in various human reproductive tissues, including semen, placenta, and ovarian follicular fluid, as well as in reproductive tissues of diverse animal species. We show a potential relationship between MNP exposure and increased prevalence of infertility and adverse pregnancy outcomes based on the fact that MNPs exert detrimental effects on reproductive parameters, including sperm quality, ovarian function, and steroidogenesis. In male reproductive systems, MNPs disrupt testicular tissue structure, impair reproductive endocrinology, and reduce sperm quality. In females, MNPs affect ovarian tissue structure and function, interfere with hormone secretion, and impact the endometrium and embryo implantation. Additionally, MNPs cause developmental toxicity in animal models, affecting embryonic development and offspring health, and produce transgenerational effects. Notably, in-depth literature study suggests a crucial role for oxidative stress, inflammation, and epigenetic modification in MNPs-induced toxicity. In conclusion, we integrated systematic knowledge on MNPs-induced reproductive and developmental toxicity, and the systematic finding underscores future study to fully elucidate the risks posed by MNPs to reproductive and developmental health and to inform policy decisions and public health interventions aimed at mitigating their harmful effects.
越来越多的证据表明，微塑料和纳米塑料（MNPs）普遍存在并在空气中、饮用水、食物中甚至在体内积累，这引起了人们对其对生殖和发育健康潜在影响的关注。为了全面评估关于 MNPs 诱导的生殖和发育毒性的现有知识状况，我们通过关注生殖组织中 MNPs 的存在及其对亲代生殖和后代发育的影响，进行了这项系统评价。我们的研究结果表明，MNPs 已在各种人类生殖组织中被检测到，包括精液、胎盘和卵巢卵泡液，以及多种动物物种的生殖组织。我们展示了 MNP 暴露与不孕和不良妊娠结局发生率增加之间的潜在关系，因为 MNPs 对生殖参数产生了有害影响，包括精子质量、卵巢功能和类固醇生成。在男性生殖系统中，MNPs 破坏睾丸组织结构，损害生殖内分泌功能，并降低精子质量。在女性中，MNPs 影响卵巢组织结构和功能，干扰激素分泌，并影响子宫内膜和胚胎着床。此外，MNPs 在动物模型中引起发育毒性，影响胚胎发育和后代健康，并产生跨代效应。值得注意的是，深入的文献研究表明，氧化应激、炎症和表观遗传修饰在 MNPs 诱导的毒性中起着关键作用。总之，我们综合了关于 MNPs 诱导的生殖和发育毒性的系统知识，这一系统发现强调了未来的研究工作，以充分阐明 MNPs 对生殖和发育健康构成的风险，并为旨在减轻其有害影响的政策决策和公共卫生干预提供信息。
