Murphy D J, Ludomirsky A, Huhta J C
Am J Cardiol. 1986 Feb 15;57(6):428-32. doi: 10.1016/0002-9149(86)90766-6.
Continuous-wave Doppler was used to estimate the pressure gradient between the right and left ventricles in 28 children with ventricular septal defect (VSD). Doppler measurement of maximal velocity was performed during cardiac catheterization and the Doppler-predicted gradient was compared with the peak-to-peak gradient measured simultaneously by catheter. Doppler gradients ranged from 10 to 71 mm Hg and correlated well with measured gradient (r = 0.97, p greater than or equal to 0.001). Fourteen patients had isolated VSD, and in these patients Doppler measurements of gradient allowed accurate estimation of right ventricular pressure (r = 0.93). There was an inverse correlation between the ratio of pulmonary to systemic resistance and maximal velocity (r = -0.77). Thus, continuous-wave Doppler is an accurate means of measuring instantaneous VSD pressure gradient in children with congenital heart disease and can be used to estimate the right ventricular and pulmonary artery pressure in children with isolated VSD. This noninvasive method can be used to distinguish restrictive from nonrestrictive VSD.
采用连续波多普勒技术对28例室间隔缺损（VSD）患儿的左右心室之间的压力阶差进行了评估。在心脏导管检查期间进行了最大速度的多普勒测量，并将多普勒预测的阶差与通过导管同时测量的峰-峰阶差进行了比较。多普勒阶差范围为10至71 mmHg，与测量阶差相关性良好（r = 0.97，p≥0.001）。14例患者为单纯室间隔缺损，在这些患者中，多普勒阶差测量能够准确估计右心室压力（r = 0.93）。肺循环与体循环阻力之比与最大速度呈负相关（r = -0.77）。因此，连续波多普勒是测量先天性心脏病患儿室间隔缺损瞬时压力阶差的准确方法，可用于估计单纯室间隔缺损患儿的右心室和肺动脉压力。这种非侵入性方法可用于区分限制性与非限制性室间隔缺损。
