在健康检查中发现的年轻消瘦轻度糖耐量异常女性中的隐匿性成年发病型糖尿病：通过孕前保健改善妊娠结局的潜力。
Hidden MODY in Young Lean Women with Mild Glucose Intolerance Detected during Health Check-ups: Potential for Improved Pregnancy Outcomes through Preconception Care.
作者信息
Osaki Aya, Ozawa Atsushi, Morita Akihito, Higeta Daisuke, Suda Shunpei, Ohtsu Yoshiaki, Yoshino Satoshi, Matsumoto Syunichi, Horiguchi Kazuhiko, Yamada Eijiro
机构信息
Division of Endocrinology and Metabolism, Department of Internal Medicine, Gunma University Graduate School of Medicine, Japan.
Division of Fundamental Nursing, Department of Nursing, Gunma University, Japan.
出版信息
Intern Med. 2025 May 15;64(10):1603-1607. doi: 10.2169/internalmedicine.4244-24. Epub 2024 Oct 25.
Mild glucose intolerance (positive urine glucose or mild hyperglycemia) during health checkups in young, lean women may require specialist consultation. We herein report a 31-year-old Japanese woman with mild hyperglycemia detected during a checkup who was diagnosed with overt diabetes in pregnancy and HNF4A-MODY postpartum, without prior follow-up. This case highlights the following: MODY may be present in young, lean women with mild glucose intolerance, and preconception care may improve pregnancy outcomes. Fetal outcomes vary with MODY subtype. Preconception care is important.
年轻、体型偏瘦的女性在健康检查时出现轻度糖耐量异常（尿糖阳性或轻度高血糖）可能需要专科会诊。我们在此报告一名31岁的日本女性，她在体检时被检测出轻度高血糖，孕期被诊断为显性糖尿病，产后被诊断为肝细胞核因子4α基因（HNF4A）突变所致的成年发病型糖尿病（MODY），此前未进行随访。该病例突出了以下几点：MODY可能存在于有轻度糖耐量异常的年轻、体型偏瘦的女性中，孕前保健可能会改善妊娠结局。胎儿结局因MODY亚型而异。孕前保健很重要。
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